Peptide-based compounds
View Patent ↗The invention relates to new peptide-based compounds for use as diagnostic imaging agents or as therapeutic agents wherein the agents comprise targeting vectors which bind to integrin receptors.
1. A compound defined by the following formulas
or pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising an effective amount of a compound of claim 1 or a salt thereof, together with one or more pharmaceutically acceptable adjuvants, excipients or diluents for use in enhancing image contrast in vivo imaging or for treatment of a disease.
3. A method of generating images of a human or animal body involving administering a contrast agent as claimed in claim 1 to said body, and generating an image of at least a part of said body to which said contrast agent has distributed.
4. A method of generating enhanced images of a human or animal body previously administered with a contrast agent composition comprising a compound as claimed in claim 1 , which method comprises generating an image of at least part of said body.
5. A method of monitoring the effect of treatment of a human or animal body with a drug to combat cancer, said method involving administering to said body a compound or composition as claimed in claim 1 and detecting the uptake of said compound or composition by cell receptors, said administration and detection optionally but preferably being effected repeatedly, e.g. before, during and after treatment with said compound or composition.
6. A compound as claimed in claim 1 wherein any of the amino acid residues are independently in the D or L conformation.