Method and compositions for treatment of acne vulgaris and acne rosacea
A topical composition for the treatment of acne vulgaris or acne rosacea comprises an amount of nicotinamide and less than 1% by weight of nicotinic acid. The composition is more effective in the treatment of acne than the same composition would be without the nicotinic acid. A method of treating acne vulgaris or acne rosacea comprises the topical application of a composition comprising nicotinamide and less than 1% by weight of nicotinic acid.
1 . A method of treating acne vulgaris and acne rosacea comprising applying to the skin of patients afflicted with such disorders a topical composition comprising an amount of nicotinamide combined with less than 1% by weight of nicotinic acid, the resulting formulation being more effective than said amount of nicotinamide by itself.
2 . The method of claim 1 wherein said composition comprises about 1-12% nicotinamide by weight.
3 . The method of claim 2 wherein said composition comprises about 2-10% nicotinamide by weight and about 0.005-0.7% nicotinic acid by weight.
4 . The method of claim 3 wherein said composition comprises about 3-7% nicotinamide by weight and about 0.05-0.2% nicotinic acid by weight.
5 . A method of treating acne vulgaris and acne rosacea comprising adding to the composition of claim 1 other known acne treatment agents.
6 . The method of claim 5 wherein said other known acne treatment agents are selected from the group consisting of clindamycin, erythromycin, retinoic acid, benzoyl peroxide, salicylic acid, azelaic acid, tazarotene, and metronidazole.
7 . A topical composition effective for treating acne vulgaris and acne rosacea comprising a pharmaceutically acceptable carrier and an amount of nicotinamide in combination with less than 1% by weight of nicotinic acid, the resulting formulation being more effective than said amount of nicotinamide by itself.
8 . The composition of claim 7 wherein said composition comprises about 1-12% nicotinamide by weight.
9 . The composition of claim 8 wherein said composition comprises about 2-10% nicotinamide by weight and about 0.005-0.7% nicotinic acid by weight.
10 . The composition of claim 9 wherein said composition comprises about 3-7% nicotinamide by weight and about 0.05-0.2% nicotinic acid by weight.
11 . The composition of claim 7 wherein other known acne treatment agents are included in the composition.
12 . The composition of claim 9 wherein the other known acne treatment agents are selected from the group consisting of clindamycin, erythromycin, retinoic acid, benzoyl peroxide, salicylic acid, azelaic acid, tazarotene, and metronidazole.