IP Library › Granted Patent US 7,674,777
Granted Patent B2
US 7,674,777 · App. 10/769,282 · Granted Mar 9, 2010

Immunostimulatory nucleic acid molecules

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Quick Facts
Patent No.
US 7,674,777
App. No.
10/769,282
Granted
Mar 9, 2010
Kind
B2
Abstract

Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.

Claims (6)

1. An immunostimulatory oligonucleotide/delivery complex, comprising: an oligonucleotide covalently linked to the surface of a biodegradable delivery complex, wherein the oligonucleotide comprises the sequence 5′-C, G-3′, wherein the C is unmethylated and wherein the oligonucleotide is 8 to 100 nucleotides in length.

2. The complex of claim 1 , wherein said complex is antigen-free.

3. The complex of claim 1 , wherein the complex further comprises an antigen.

4. A composition comprising a complex of claim 1 and a pharmaceutically acceptable carrier.

5. The complex of claim 1 , wherein said oligonucleotide comprises the sequence 5′-T, C, G-3′.

6. The complex of claim 1 , wherein said oligonucleotide comprises the sequence 5′-C, G, pyrimidine, pyrimidine, C, G-3′.

Assignments (8)
CONFIRMATORY LICENSE Recorded Aug 10, 2010
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024819/0268 →
CONFIRMATORY LICENSE Recorded Jun 10, 2010
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024505/0947 →
CONFIRMATORY LICENSE Recorded Oct 10, 2008
From: UNIVERSITY OF IOWA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 021670/0825 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2004
From: STEINBERG, ALFRED D.
To: CPG IMMUNOPHARMACEUTICALS, INC.
Reel/Frame 014473/0965 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2004
From: KLINMAN, DENNIS
To: DEPARTMENT OF HEALTH AND HUMAN SERVICES, UNITED STATES OF AMERICA, THE, AS REPRESENTED BY THE SECRETARY
Reel/Frame 014473/0967 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2004
From: KRIEG, ARTHUR M.
To: UNIVERSITY OF IOWA RESEARCH FOUNDATION, THE
Reel/Frame 014473/0989 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2004
From: KLINE, JOEL
To: IOWA UNIVERSITY RESEARCH FOUNDATION OF, THE
Reel/Frame 014473/0935 →
CHANGE OF NAME Recorded Mar 30, 2004
From: CPG IMMUNOPHARMACEUTICALS, INC.
To: COLEY PHARMACEUTICAL GROUP, INC.
Reel/Frame 014473/0953 →