Drug formulation and delivery using crystalline methylated cyclodextrins
View Patent ↗The present invention is directed to pharmaceutical compositions containing crystalline methylated cyclodextrins, which enhance the solubility of the pharmaceutically active agent or agents of the formulation.
1. A pharmaceutical composition, comprising a solubilizing agent selected from crystalline methylated α-, β-, and γ-cyclodextrin, or mixtures thereof, and a pharmaceutically active agent.
2. The composition of claim 1 , wherein the solubilizing agent is crystalline methylated β-cyclodextrin.
3. The composition of claim 1 , wherein the active agent is one that has poor aqueous solubility.
4. The composition of claim 1 , which is an oral or parenteral solution.
5. The composition of claim 1 , which is a liquid or cream preparation for external use.
6. The composition of claim 1 , which is in the form of a solid dosage unit.
7. The composition of claim 1 , which is a solid oral dosage unit.
8. The composition of claim 1 , which is a tablet or capsule.
9. The composition of claim 1 , which is an osmotic dosage unit.
10. The composition of claim 1 , wherein the active agent is carbamazepine, fenofibrate, oxcarbazepine, or glipizide.