Ultrashort-acting opioids for transdermal applications
View Patent ↗The subject invention encompasses compounds of the formula: wherein R 1 , R 2 , and R 3 are as defined herein. The subject invention also concerns methods for synthesizing the compounds of the invention. The invention also concerns compositions comprising the above compounds as well as methods for treating pain in a patient, where the method comprises administering a compound of the invention to a patient in need of such treatment.
1. The opioid compounds having the following structure:
wherein, R 1 and R 2 are, independently, H or CH 3 and R 3 is alkyl, provided that when R 3 is methyl, then R 1 and R 2 are not simultaneously H.
2. A compound according to claim 1 , wherein R 3 is C 1 –C 8 alkyl.
3. A compound according to claim 2 , wherein R 3 is methyl, ethyl, isopropyl, or tert-butyl.
4. A composition comprising a compound of claim 1 and a pharmaceutical carrier.
5. A composition according to claim 4 , wherein R 3 is C 1 –C 8 alkyl.
6. A composition according to claim 5 , wherein R 3 is methyl, ethyl, isopropyl, or tert-butyl.
7. A method of treating pain comprising administering a compound of claim 1 to a patient in need of such treatment.
8. The method of claim 7 , wherein R 3 is C 1 –C 8 alkyl.
9. The method of claim 8 , wherein R 3 is methyl, ethyl, isopropyl, or tert-butyl.
10. The method of claim 7 , wherein the patient is a human.