IP Library › Granted Patent US 7,320,982
Granted Patent B2
US 7,320,982 · App. 10/773,073 · Granted Jan 22, 2008

Use of 4-substituted tetrahydropyridines for the manufacture of medicaments acting upon TGF-β 1

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Quick Facts
Patent No.
US 7,320,982
App. No.
10/773,073
Granted
Jan 22, 2008
Kind
B2
Abstract

The invention relates to the use of a compound of formula (I): for the preparation of pharmaceutical compositions for increasing the circulating, cellular and extracellular levels of TGF-β1.

Claims (1)

1. A method of inhibiting apoptosis in a patient with prion disease which comprises administering an effective amount of a compound selected from 1-[2-(6,7-methylenedioxynaphth-2-yl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine, 1-[2-(4-cyclohexenylphenyl)-ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine and 1-[2-biphenyl-4-yl)ethyl]-4-(2-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine or a pharmaceutically acceptable salt thereof.