Hetero-substituted acetanilide derivatives as analgesic agents
View Patent ↗Hetero-substituted acetanilide derivatives are disclosed as analgesic agents. The compounds of the invention are useful in methods for treating a disease or condition in a mammal characterized by pain and/or fever.
1. A composition comprising compounds of formula (I):
wherein R 3 is hydrogen and R 1 and R 2 taken together form an optionally substituted pyrrole; tautomers, or pharmaceutically acceptable salts thereof.
2. A composition comprising a compound selected from the group consisting of:
1H-pyrrole-2-carboxylic acid (4-hydroxy-phenyl)-amide;
and tautomers, or pharmaceutically acceptable salts thereof.
3. A compounds of formula (I):
wherein R 3 is hydrogen and R 1 and R 2 taken together form an optionally substituted pyrrole, tautomers, or pharmaceutically acceptable salts thereof.
4. A compound selected from the group consisting of:
1H-pyrrole-2-carboxylic acid (4-hydroxy-phenyl)-amide;
and tautomers, or pharmaceutically acceptable salts thereof.
5. A method of controlling pain or fever in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound of formula (I):
wherein R 3 is hydrogen and R 1 and R 2 taken together form an optionally substituted pyrrole, tautomers, or pharmaceutically acceptable salts thereof.
6. A method of controlling pain or fever in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound selected from the group consisting of:
1H-pyrrole-2-carboxylic acid (4-hydroxy-phenyl)-amide;
and tautomers, or pharmaceutically acceptable salts thereof.