Hydrazide and alkoxyamide angiogenesis inhibitors

1. A compound of formula (I),

or a therapeutically acceptable salt or prodrug thereof, wherein

R 1 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, (cycloalkyl)alkyl, (heterocycle)alkyl, and R 5 S-(alkylene)-;

wherein each group is drawn with its right-hand end being the end that is attached to the parent molecular moiety;

R 3 is selected from the group consisting of hydrogen, alkyl, and arylalkyl;

R 4 is selected from the group consisting of —NR 6 R 7 , and —OR 8 ;

wherein each group is drawn with its left-hand end being the end that is attached to the parent molecular moiety;

R 5 is selected from the group consisting of alkyl, aryl, arylalkyl, cycloalkyl, and (cycloalkyl)alkyl;

R 6 and R 7 are independently selected from the group consisting of hydrogen, alkanoyl, alkenyl, alkenyloxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylsulfanylalkyl, aryl, arylalkanoyl, arylalkoxyalkyl, arylalkoxycarbonyl, arylalkyl, aryloxyalkyl, (aryl)oyl, arylsulfonyl, carboxyalkyl, cycloalkyl, (cycloalkyl)alkyl, (cycloalkyl)alkanoyl, (cycloalkyl)oyl, haloalkanoyl, haloalkyl, heterocycle, (heterocycle)alkanoyl, (heterocycle)oyl, hydroxyalkyl, a nitrogen protecting group, and —C(O)NR 9 R 10 ; or

R 6 and R 7 together are arylalkylidene; or

R 6 and R 7 , together with the nitrogen atom to which they are attached, form a heterocycle;

R 8 is selected from the group consisting of hydrogen, alkanoylalkyl, alkenyl, alkoxycarbonylalkyl, alkyl, amidoalkyl, aryl, arylalkyl, arylalkoxycarbonylalkyl, (aryl)oylalkyl, carboxyalkyl, and (cycloalkyl)alkyl; and

R 9 and R 10 are independently selected from the group consisting of hydrogen, alkyl and aryl.

2. A compound according to claim 1 , wherein R 1 is selected from the group consisting of alkyl, cycloalkyl, (cycloalkyl)alkyl, arylalkyl, and (heterocycle)alkyl.

3. A compound according to claim 2 , wherein R 4 is —OR 8 .

4. A compound according to claim 3 selected from the group consisting of

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-phenoxybutanamide;

(2RS,3R)-3-amino-N-(benzyloxy)-4-cyclohexyl-2-hydroxybutanamide;

(2RS,3R)-3-amino-N-(methoxy)-4-cyclohexyl-2-hydroxybutanamide;

(2RS,3R)-3-amino-N-(tert-butoxy)-4-cyclohexyl-2-hydroxybutanamide;

(2RS,3R)-3-amino-4-cyclohexyl-N-ethoxy-2-hydroxybutanamide;

(2RS,3R)-N-(allyloxy)-3-amino-4-cyclohexyl-2-hydroxybutanamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-isobutoxybutanamide;

(2RS,3R)-3-amino-4-cyclohexyl-N,2-dihydroxybutanamide;

(2RS,3R)-3-amino-3-cyclohexyl-2-hydroxy-N-phenoxypropanamide;

(2RS,3R)-3-amino-5-phenyl-2-hydroxy-N-phenoxypentanamide;

(2RS,3R)-3-amino-3-cyclooctyl-2-hydroxy-N-phenoxypropanamide;

(2RS,3R)-3-amino-5-cyclohexyl-2-hydroxy-N-phenoxypentanamide;

ethyl ((((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)amino)oxy)acetate;

benzyl ((((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)amino)oxy)acetate;

((((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)amino)oxy)acetic acid;

ethyl (2S)-2-((((((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)amino)oxy)acetyl)amino)propanoate;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(2-oxo-2-((2-phenylethyl)amino)ethoxy)butanamide;

(2RS,3R)-3-amino-N-(benzyloxy)-3-cyclohexyl-2-hydroxypropanamide; and

(2RS,3R)-3-amino-N-(benzyloxy)-2-hydroxy-5-phenylpentanamide.

5. A compound according to claim 2 wherein R 4 is —NR 6 R 7 .

6. A compound according to claim 5 wherein one of R 6 and R 7 is hydrogen and the other is (aryl)oyl.

7. A compound according to claim 6 selected from the group consisting of

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-1-naphthohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-ethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,5-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,5-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,4-dihydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,5-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-nitrobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-naphthohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-chlorobenzohydrazide;

(2RS,3R)-3-amino-N′-benzoyl-4-cyclohexyl-2-hydroxybutanohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-tert-butylbenzohydrazide;

N′-((2RS,3R)-3-amino-3-cyclohexyl-2-hydroxypropanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-phenylpentanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-3-cyclooctyl-2-hydroxypropanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-cyclohexyl-2-hydroxypentanoyl)-3-chlorobenzohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-phenyl-N′-(1-naphthyl)pentanohydrazide;

N′-((2RS,3R)-3-amino-3-cyclohexyl-2-hydroxypropanoyl)-2-naphthohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-1-naphthohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-hydroxy-2-naphthohydrazide;

N′-((2S,3R)-3-amino-2-hydroxy-5-phenylpentanoyl)-1-naphthohydrazide;

N′-((2S,3R)-3-amino-2-hydroxy-5-phenylpentanoyl)-3-hydroxy-2-naphthohydrazide;

N′-((2S,3R,4RS)-3-amino-4-ethyl-2-hydroxyoctanoyl)-3-chlorobenzohydrazide;

N′-((2S,3R)-3-amino-5-cyclohexyl-2-hydroxypentanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-methylbenzohydrazide;

2-amino-N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)benzohydrazide;

4-amino-N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)benzohydrazide;

3-amino-N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-cyanobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-cyanobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-(dimethylamino)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-(dimethylamino)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-(trifluoromethyl)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-(trifluoromethyl)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-(trifluoromethoxy)benzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-4-phenoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,4-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,5-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,4-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,5-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,3-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,4-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,4,5-trimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,3-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,4-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,4-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3,5-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,3-dimethylbenzohydrazide;

(2S,3R)-3-amino-N′-(3-chlorobenzoyl)-2-hydroxy-5-phenylpentanohydrazide; and

(2S,3R)-3-amino-N′-(3-chlorobenzoyl)-2-hydroxy-5-(1H-indol-3-yl)pentanohydrazide.

8. A compound according to claim 5 wherein one of R 6 and R 7 is selected from the group consisting of hydrogen, alkyl, and aryl; and the other is selected from the group consisting of hydrogen, aryl, and arylalkyl.

9. A compound according to claim 8 selected from the group consisting of

(2RS,3R)-3-amino-N′-benzyl-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-benzyl-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-phenylethyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-methyl-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-methylphenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-methoxyphenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(1-naphthyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2,4-difluorophenyl)-2-hydroxybutanohydrazide;

4-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)benzenesulfonamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-N′-(4-bromophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-methylphenyl)butanohydrazide;

(2RS,3R)-3-amino-N′-(2-chlorophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(3-(trifluoromethyl)phenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-iodophenyl)butanohydrazide;

(2RS,3R)-3-amino-N′-(3-chlorophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(3-methoxyphenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(3,5-dichlorophenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-(3-bromophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-isopropylphenyl)butanohydrazide;

(2RS,3R)-3-amino-N′-(3-chloro-4-methylphenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-(trifluoromethoxy)phenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(4-fluorophenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-(4-chlorophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2-ethylphenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(3-fluorophenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-(4-chloro-2-methylphenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-mesitylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-((E)-2-(2-pyridinyl)ethenyl)phenyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2-fluorophenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-(trifluoromethyl)phenyl)butanohydrazide;

(2RS,3R)-3-amino-N′-(2-chloro-6-fluorophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2,5-difluorophenyl)-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-(3-chloro-4-fluorophenyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-N′-(2-chlorobenzyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-(3-phenylpropyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-isobutyl-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-pentyl-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((2RS)-2-methylbutyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-isopentyl-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-hexyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((2RS)-2-methylpentyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((3RS)-3-methylpentyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(3,3-dimethylbutyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2-ethylbutyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-dodecyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-((3RS)-3,5,5-trimethylhexyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-octyl-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-propylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-heptyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-ethyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-(4-methylphenyl)ethyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-((2RS)-2-ethylhexyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-N′-((2RS)-2-(4-chlorophenyl)-2-cyanoethyl)-4-cyclohexyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-((2RS)-2-phenylpropyl)butanohydrazide;

(2RS,3R)-3-amino-3-cyclohexyl-2-hydroxy-N′-(4-methylphenyl)propanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-phenyl-N′-(4-methylphenyl)pentanohydrazide;

(2S,3R)-3-amino-3-cyclooctyl-2-hydroxy-N′-(4-methylphenyl)propanohydrazide;

(2RS,3S)-3-amino-4-((cyclohexylmethyl)sulfanyl)-2-hydroxy-N′-(4-methylphenyl)butanohydrazide;

(2RS,3R)-3-amino-3-cyclohexyl-2-hydroxy-N′-(1-naphthyl)propanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-phenyl-N′-(1-naphthyl)pentanohydrazide;

(2RS,3R)-3-amino-3-cyclooctyl-2-hydroxy-N′-(1-naphthyl)propanohydrazide;

(2RS,3R)-3-amino-5-cyclohexyl-2-hydroxy-N′-(4-methylphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-cyclohexyl-2-hydroxy-N′-(1-naphthyl)pentanohydrazide; and

(2S,3R)-3-amino-4-cyclohexyl-2-hydroxybutanohydrazide.

10. A compound according to claim 5 wherein one of R 6 and R 7 is selected from the group consisting of hydrogen, alkyl, and aryl; and the other is selected from the group consisting of alkanoyl, alkenyl, alkenyloxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkylsulfanylalkyl, aryloxyalkyl, arylalkoxycarbonyl, arylsulfonyl, carboxyalkyl, —C(O)R 9 R 10 , cycloalkyl, (cycloalkyl)alkyl, haloalkanoyl, haloalkyl, heterocycle, (heterocycle)oyl, and hydroxyalkyl.

11. A compound according to claim 10 selected from the group consisting of

(2RS,3R)-3-amino-N′-(7-chloro-4-quinolinyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-N-(4-iodophenyl)hydrazinecarboxamide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-2,4,6-trimethylbenzenesulfonohydrazide;

ethyl (2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)acetate trifluoroacetate;

benzyl 2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazinecarboxylate;

ethyl 3-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)-3-oxopropanoate;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2,2,2-trifluoroethyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-methyl-N′-(3-nitro-2-pyridinyl)butanohydrazide;

(2RS,3R)-3-amino-N′,4-dicyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-pyridinyl)butanohydrazide;

(2RS,3R)-3-amino-N′-(6-chloro-3-pyridazinyl)-4-cyclohexyl-2-hydroxy-N′-methylbutanohydrazide;

(2RS,3R)-3-amino-N′-(5-chloro-1-methyl-6-oxo-1,6-dihydro-4-pyridazinyl)-4-cyclohexyl-2-hydroxy-N′-methylbutanohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-1,3-benzodioxole-5-carbohydrazide;

methyl 2-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)-4-(trifluoromethyl)-5-pyrimidinecarboxylate;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((2RS)-2-hydroxy-3-(3-(trifluoromethyl)phenoxy)propyl)-N′-methylbutanohydrazide;

methyl 3-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)-2-thiophenecarboxylate;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-pyridinylcarbonyl)butanohydrazide;

ethyl 3-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)-6,6-dimethyl-4-oxo-4,5,6,7-tetrahydro-2-benzothiophene-1-carboxylate;

(2RS,3R)-3-amino-N′-(1,3-benzothiazol-2-yl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(trifluoroacetyl)butanohydrazide;

N′-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-3-chloro-1-benzothiophene-2-carbohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-quinoxalinyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-methyl-N′-(5-(trifluoromethyl)-2-pyridinyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(1,3-dimethyl-4-nitro-1H-pyrazol-5-yl)-2-hydroxybutanohydrazide;

2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-N-phenylhydrazinecarboxamide;

2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-N-(4-chloro-2-methoxyphenyl)hydrazinecarboxamide;

2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-N-(3-fluorophenyl)hydrazinecarboxamide;

N-((1R)-1-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)carbonyl)-3-(methylsulfanyl)propyl)-4-(trifluoromethyl)benzamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(2-thienylcarbonyl)butanohydrazide;

4-chlorobenzyl 2-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)hydrazino)-4-(trifluoromethyl)-5-pyrimidinecarboxylate;

(2RS,3R)-3-amino-N′-(6-chloro-3-pyridazinyl)-4-cyclohexyl-2-hydroxybutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((3RS)-3-(methylsulfanyl)butyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(cyclopropylmethyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-N′-(2-(benzyloxy)ethyl)-4-cyclohexyl-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-(2,2,5-trichloropentyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(3-(methylsulfanyl)propyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(cyclopentylmethyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(5-hydroxypentyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-((2R)-2,3-dihydroxypropyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2,2-dichlorohexyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((3RS)-7-methoxy-3,7-dimethyloctyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(cyclooctylmethyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-((11Z)-11-hexadecenyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-tridecylbutanohydrazide;

4-(2-((2RS,3R)-3-amino-4-cyclohexyl-2-hydroxybutanoyl)-1-phenylhydrazino)butanoic acid;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((6Z)-6-nonenyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-((4Z)-4-decenyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-(4-pentenyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-((3RS)-3,7-dimethyl-6-octenyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-phenyl-N′-(4,4,4-trifluorobutyl)butanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N′-((3RS)-3-hydroxybutyl)-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2-(((3RS)-3,7-dimethyl-6-octenyl)oxy)ethyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-4-cyclohexyl-N′-(2-((1RS)-3,3-dimethylcyclohexyl)ethyl)-2-hydroxy-N′-phenylbutanohydrazide;

(2RS,3R)-3-amino-N′-((4S)-6-bromo-4-methylhexyl)-4-cyclohexyl-2-hydroxy-N′-phenylbutanohydrazide; and

(2RS,3R)-3-amino-4-cyclohexyl-N′-(cyclohexylmethyl)-2-hydroxy-N′-phenylbutanohydrazide.

12. A compound according to claim 5 wherein R 6 and R 7 together are arylalkylidene.

13. A compound according to claim 12 which is

(2RS,3R)-3-amino-N′-((E)-(4-chlorophenyl)methylidene)-4-cyclohexyl-2-hydroxybutanohydrazide.

14. A compound according to claim 5 wherein R 6 and R 7 , together with the nitrogen atom to which they are attached, form a heterocycle.

15. A compound according to claim 14 selected from the group consisting of

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-((2S)-2-(methoxymethyl)pyrrolidinyl)butanamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(1-pyrrolidinyl)butanamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(4-oxo-2-thioxo-1,3-thiazolidin-3-yl)butanamide;

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-(1-piperidinyl)butanamide; and

(2RS,3R)-3-amino-4-cyclohexyl-2-hydroxy-N-((2R)-2-(methoxymethyl)pyrrolidinyl)butanamide.

16. A compound according to claim 1 wherein R 1 is R 5 S-(alkylene)-.

17. A compound according to claim 16 wherein R 4 is —OR 8 .

18. A compound according to claim 17 selected from the group consisting of

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-phenoxypentamide;

(2RS,3S)-3-amino-4-(ethylsulfanyl)-2-hydroxy-N-phenoxybutanamide;

(2RS,3S)-3-amino-2-hydroxy-N-phenoxy-4-(propylsulfanyl)butanamide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N-phenoxypentanamide;

(2RS,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)-N-phenoxybutanamide;

(2RS,3S)-3-amino-4-((cyclohexylmethyl)sulfanyl)-2-hydroxy-N-phenoxybutanamide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-benzyloxypentanamide;

(2RS,3R)-3-amino-N-(benzyloxy)-2-hydroxy-5-(isopropylsulfanyl)pentanamide;

(2RS,3S)-3-amino-N-(benzyloxy)-2-hydroxy-4-(isobutylsulfanyl)butanamide;

(2S,3S)-3-amino-N-(cyclohexylmethoxy)-2-hydroxy-4-(isobutylsulfanyl)butanamide;

(2S,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)-N-(mesitylmethoxy)butanamide;

(2RS,3R)-3-amino-2-hydroxy-5-(ethylsulfanyl)-N-((1RS)-1-phenylethoxy)pentanamide;

(2S,3S)-3-amino-N-(benzyloxy)-2-hydroxy-4-(isobutylsulfanyl)-N-methylbutanamide;

(2RS,3S)-3-amino-N-(benzyloxy)-2-hydroxy-5-(isopropylsulfanyl)-N-methylpentanamide; and

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N-((1RS)-1-phenylethoxy)pentanamide.

19. A compound according to claim 18 wherein R 4 is —NR 6 R 7 .

20. A compound according to claim 19 wherein one of R 6 and R 7 is hydrogen and the other is (aryl)oyl.

21. A compound according to claim 20 wherein the aryl(oyl) is unsubstituted.

22. A compound according to claim 21 selected from the group consisting of

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-naphthohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-isopropylsulfanylpentanoyl)-2-naphthohydrazide;

N′-((2RS,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)butanoyl)-2-naphthohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1-naphthohydrazide; and

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-1-naphthohydrazide.

23. A compound according to claim 20 wherein the aryl(oyl) is substituted with one substituent.

24. A compound according to claim 23 wherein the substituent is at the 2-position.

25. A compound according to claim 24 selected from the group consisting of

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-hydroxy-2-naphthohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-aminobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-ethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-benzylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-anilinobenzohydrazide; and

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-(2-phenylethyl)benzohydrazide.

26. A compound according to claim 23 wherein the substituent is at the 3-position.

27. A compound according to claim 23 selected from the group consisting of

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3S)-3-amino-4-(ethylsulfanyl)-2-hydroxybutanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3S)-3-amino-2-hydroxy-4-(propylsulfanyl)butanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)butanoyl)-3-chlorobenzohydrazide;

N′-((2RS,3S)-3-amino-4-((cyclohexylmethyl)sulfanyl)-2-hydroxybutanoyl)-3-chlorobenzohydrazide;

N′-((2S,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl-3-chlorobenzohydrazide

N′-((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-chlorobenzohydrazide;

N′-((2R,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-chlorobenzohydrazide;

N′-((2R,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-chlorobenzohydrazide;

3-(2-aminoethyl)-N′-((2S,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)butanoyl)benzohydrazide;

N′-((2S,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)butanoyl)-3-propoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-trifluoromethylsulfanylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-aminobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-(dimethylamino)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-(trifluoromethyl)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-(trifluoromethoxy)benzohydrazide;

(2RS,3R)-3-amino-N′-(3-(2-aminoethoxy)phenyl)-2-hydroxy-5-(isopropylsulfanyl)pentanohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-cyanobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(methylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(ethylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(propylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(butylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(hexylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(isopropylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(isobutylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentnoyl)-3-((4-methylpentyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(sec-butylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(neopentylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(cyclohexylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-((cyclohexylmethyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(benzylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-((2-phenylethyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-((3-phenylpropyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-(((1,1′-biphenyl)-4-ylmethyl)sulfanyl)benzohydrazide; and

(2RS,3R)-3-amino-N′-(3-(2,3-dihydroxypropoxy)benzoyl)-2-hydroxy-5-(isopropylsulfanyl)pentanohydrazide.

28. A compound according to claim 23 wherein the substituent is at the 4-position.

29. A compound according to claim 28 selected from the group consisting of

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-aminobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-hydroxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-bromobenzohydrazide; N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-isopropylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-propoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-(methylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-isopropoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-(diethylamino)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-butoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-(dimethylamino)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-(trifluoromethyl)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-phenoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-(phenoxymethyl)benzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-cyanobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-fluorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-chlorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-bromobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-ethylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-propylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-isopropylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-ethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-tert-butylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-propoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-isopropoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(methylsulfonyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(methylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(ethylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(propylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(butylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(hexylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(isopropylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(isobutylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-((4-methylpentyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(sec-butylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(neopentylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(cyclohexylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-((cyclohexylmethyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(benzylsulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-((2-phenylethyl)sulfanyl)benzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-((3-phenylpropyl)sulfanyl)benzohydrazide; and

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-(((1,1′-biphenyl)-4-ylmethyl)sulfanyl)benzohydrazide.

30. A compound according to claim 20 wherein the aryl(oyl) is substituted with two or three substituents.

31. A compound according to claim 30 selected from the group consisting of

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,4-diethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,3-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,4-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,5-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4,5-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,5-dimethylbenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,3-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,4-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,5-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,4-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,5-dimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,4,5-trimethoxybenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,3-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,4-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2,5-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,4-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3,5-dichlorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2,3-dichlorobenzohydrazide; N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-fluoro-2-methylbenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2,3-difluorobenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-5-chloro-2-methoxybenzohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-chloro-5-(methylsulfanyl)benzohydrazide; and

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3,4-diethoxybenzohydrazide.

32. A compound according to claim 19 wherein one of R 6 and R 7 is hydrogen; and the other is selected from the group consisting of aryl, arylalkanoyl, arylalkoxycarbonyl, and arylsulfonyl.

33. A compound according to claim 32 selected from the group consisting of

benzyl 2-((2RS,3S)-3-amino-4-((cyclohexylmethyl)sulfanyl)-2-hydroxybutanoyl)hydrazinecarboxylate;

benzyl 2-((2RS,3S)-3-amino-2-hydroxy-4-(propylsulfanyl)butanoyl)hydrazinecarboxylate;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-methylphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-methoxyphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(1-naphthyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-iodophenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-chlorophenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-methoxyphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(2-chlorophenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-trifluoromethylphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-isopropyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-chloro-4-methylphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-fluorophenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(2-ethylphenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-fluorophenyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(4-trifluoromethoxyphenyl)pentanohydrazide;

(2RS,3S)-3-amino-4-(ethylsulfanyl)-2-hydroxy-N′-(4-methylphenyl)butanohydrazide;

(2RS,3S)-3-amino-2-hydroxy-N′-(4-methylphenyl)-4-(propylsulfanyl)butanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-(4-methylphenyl)pentanohydrazide;

(2RS,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)-N′-(4-methylphenyl)butanohydrazide;

(2RS,3S)-3-amino-4-(ethylsulfanyl)-2-hydroxy-N′-(1-naphthyl)butanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-(1-naphthyl)pentanohydrazide;

(2RS,3S)-3-amino-2-hydroxy-4-(isobutylsulfanyl)-N′-(1-naphthyl)butanohydrazide;

(2RS,3S)-3-amino-2-hydroxy-N′-(1-naphthyl)-4-(propylsulfanyl)butanohydrazide;

(2RS,3S)-3-amino-4-((cyclohexylmethyl)sulfanyl)-2-hydroxy-N′-(1-naphthyl)butanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(phenylacetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((2-methoxyphenyl)acetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((3-methoxyphenyl)acetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((4-methoxyphenyl)acetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((2-chlorophenyl)acetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((3-chlorophenyl)acetyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-((4-chlorophenyl)acetyl)pentanohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(1,1′-biphenyl)-4-ylacetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(4-dimethylaminophenyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(1-naphthyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(2-naphthyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)benzenesulfonohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-chlorobenzenesulfonohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1-naphthalenesulfonohydrazide; and

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-methylbenzenesulfonohydrazide.

34. A compound according to claim 19 wherein one of R 6 and R 7 is hydrogen; and the other is selected from the group consisting of alkanoyl, cycloalkyl, cycloalkylalkanoyl, (cycloalkyl)oyl, (heterocycle)alkanoyl, and (heterocycle)oyl.

35. A compound according to claim 34 selected from the group consisting of

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-cyclopentylpentanohydrazide;

(2RS,3R)-N′-acetyl-3-amino-5-(ethylsulfanyl)-2-hydroxypentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-isobutyrylpentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(3-methylbutanoyl)pentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-N′-heptanoyl-2-hydroxypentanohydrazide;

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N′-(tetrahydro-2-furanylcarbonyl)pentanohydrazide;

(2RS,3R)-3-amino-N′-(cyclohexylacetyl)-5-(ethylsulfanyl)-2-hydroxyheptanohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-furohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-furohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1H-pyrrole-2-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1,3-thiazole-2-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1,3-thiazole-4-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1,3-thiazole-5-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1H-pyrazole-5-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1H-pyrazole-4-carbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-5-isoxazolecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-pyridinecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(2-pyridinyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-pyridinecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(3-pyridinyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-pyridinecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-(4-pyridinyl)acetohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-3-pyridazinecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-4-pyrimidinecarbohydrazide;

N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-2-pyrazinecarbohydrazide;

(2RS,3R)-3-amino-N′-((2RS,3S)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-hydroxy-5-(isopropylsulfanyl)pentanohydrazide; N′-((2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxypentanoyl)-1,3-benzodioxole-5-carbohydrazide;(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-(tetrahydro-2-furanylcarbonyl)pentanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-(tetrahydro-3-furanylcarbonyl)pentanohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-cyclopentylpentanohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-cyclopentylacetohydrazide;

(2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)-N′-cyclohexylpentanohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-cyclohexylacetohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-furohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-furohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2,5-dimethyl-3-furohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-methyl-2-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-5-methyl-2-thiophenecarbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-1H-pyrrole-2-carbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-1-methyl-1H-pyrrole-2-carbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-1,3-thiazole-2-carbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-1,3-thiazole-4-carbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-isopropylpentanoyl)-2-pyridinecarbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-6-chloro-2H-chromene-3-carbohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-(4-morpholinyl)acetohydrazide;

N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-2-(4-methyl-1-piperazinyl)acetohydrazide; and

1-acetyl-N′-((2RS,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-4-piperidinecarbohydrazide.

36. A compound according to claim 19 wherein R 6 and R 7 , together with the nitrogen atom to which they are attached, form a heterocycle.

37. A compound according to claim 36 which is

(2RS,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-(1-piperidinyl)pentanamide.

38. A pharmaceutical composition comprising a compound of claim 1 or a therapeutically acceptable salt or prodrug thereof, in combination with a therapeutically acceptable carrier.

39. A method of inhibiting angiogenesis in a mammal in recognized need of such treatment comprising administering to the mammal a therapeutically acceptable amount of a compound of claim 1 .

40. A compound which is

N′-((2S,3R)-3-amino-2-hydroxy-5-(isopropylsulfanyl)pentanoyl)-3-chlorobenzoyl hydrazide.