Medical device with adherent coating, and method for preparing same
View Patent ↗A medical device such as a wire guide has a lubricious and/or therapeutic coating adhered to an etched, carbonaceous polymeric surface, for example a sodium-etched polymer surface. A method for preparing a lubricious and/or therapeutic coating on a medical device includes etching a polymeric portion of the device to create a carbonaceous surface and applying a lubricious and/or therapeutic coating on the etched surface.
1. A medical wire guide, comprising:
an elongate wire;
a fluoropolymer coating on said elongate wire, said fluoropolymer coating including an etched carbonaceous surface, said etched carbonaceous surface including oxygen-containing organic groups formed at positions at which fluorine atoms of said fluoropolymer coating have been removed; and
a lubricious and/or therapeutic coating adhered to said etched carbonaceous surface.
2. The medical wire guide of claim 1 , wherein the fluoropolymer is polytetrafluoroethylene.
3. The medical wire guide of claim 1 , which is an exchange wire guide.
4. The medical wire guide of claim 1 , including at least one system of indicia thereon.
5. The medical wire guide of claim 1 , having a lubricious coating adhered to said etched carbonaceous surface.
6. The medical wire guide of claim 5 , wherein said lubricious coating comprises one or more polymers non-covalently adhered to the carbonaceous surface.
7. The medical wire guide of claim 5 , wherein said lubricous coating comprises polyvinylpyrrolidone or a copolymer thereof.
8. A medical device, comprising:
an elongate member for traversing a bodily passage;
the elongate member including a fluoropolymer portion having an etched carbonaceous surface, said etched carbonaceous surface including oxygen-containing organic groups formed at positions at which fluorine atoms of said fluoropolymer portion have been removed; and
a lubricous and/or therapeutic coating on said surface.
9. The medical device of claim 8 , wherein the fluoropolymer is polytetrafluoroethylene.
10. The medical device of claim 8 , which is a catheter or wire guide.
11. A medical device, comprising:
a member for traversing or implantation within a bodily passage;
the member having an etched fluoropolymer portion having a carbonaceous surface, said carbonaceous surface including oxygen-containing organic groups formed at positions at which fluorine atoms of said fluoropolymer portion have been removed; and
a lubricious and/or therapeutic coating adhered to said carbonaceous surface.
12. The medical device of claim 11 , which is a wire guide, catheter, or stent.
13. The medical device of claim 11 , wherein a lubricous coating is adhered to said carbonaceous surface.
14. The medical device of claim 11 , wherein a therapeutic coating is adhered to said carbonaceous surface, the therapeutic coating containing an antibiotic or anti-thrombogenic agent.
15. A medical wire guide, comprising:
an elongate member having a fluoropolymer surface;
said fluoropolymer surface having been treated to remove fluorine atoms and form oxygen-containing organic groups to increase the hydrophilic character of the fluoropolymer surface; and
a lubricious and/or therapeutic coating adhered to the treated fluoropolymer surface.
16. The medical wire guide of claim 15 , which has a lubricious coating adhered to the treated fluoropolymer surface.
17. The medical wire guide of claim 16 , wherein the lubricious coating also includes a therapeutic agent.
18. The medical wire guide of claim 15 , wherein the fluoropolymer is polytetrafluoroethylene.