IP Library Granted Patent US 6,976,949
Granted Patent B2
US 6,976,949 · App. 10/784,083 · Granted Dec 20, 2005

Treatment of spinal metastases

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 6,976,949
App. No.
10/784,083
Granted
Dec 20, 2005
Kind
B2
Abstract

A radiotherapy system, and preferably a brachytherapy system, for delivering radiation to tissue surrounding an interstitial space is provided. While the system can be used for a variety of purposes, the system is preferably used to treat spinal metastases. In general, the system includes a catheter member having a proximal end, a distal end, and an inner lumen extending therethrough, and a structural support adapted to fit within an interstitial space in load bearing portion of a patient's body and having an internal space for removably receiving the distal end of the catheter member. At least one anchoring element can be disposed proximate to the distal end of the catheter. The anchoring element is preferably adapted to fit within the internal space in the structural support so as to anchor the distal end of the catheter therein. The system further includes a radiation source disposable within the internal space of the structural support through the lumen in the catheter for delivering radiation to tissue surrounding the interstitial space.

Claims (19)

1. A system for treating metastases in a load bearing portion of a patient's body, comprising:

a structural support adapted to fit within a cavity in a patient's spine and to structurally stabilize the load bearing portion, the structural support defining an internal space;

a radiation source positionable within the internal space for delivering radiation to tissue surrounding the cavity.

2. The system of claim 1 , further comprising a shield, the shield being adapted to shield radiation sensitive tissue from a portion of the radiation.

3. The system of claim 1 , wherein the structural support is configured to fit within a cavity in a patient's bone.

4. The system of claim 1 , wherein a portion of the structural support adapted to be positioned adjacent a patient's spine is formed from a radio-opaque material adapted to shield the patient's spinal cord from radiation.

5. The system of claim 1 , wherein the radiation source is configured to provide an asymmetric radiation dose within the tissue surrounding the cavity so that radiation sensitive tissue surrounding the cavity receives a lesser dose.

6. The system of claim 1 , wherein the structural support and the radiation source are adapted so that the radiation source is positioned at a predetermined distance apart from tissue surrounding the cavity so as to provide a prescribed absorbed dose of radiation to the surrounding tissue to a predetermined depth.

7. A method for treating metastases in a patient's spine, comprising:

placing a structural support within an interstitial space in the spine to provide structural support therein;

placing a radiation source within the structural support; and

providing a controlled dose of radiation to tissue surrounding the structural support.

8. The method of claim 7 , further comprising surgically resecting a vertebral body to at least partially create an interstitial space.

9. The method of claim 7 , wherein a radiation shield is provided, the shield being adapted to shield radiation sensitive tissue from a portion of the radiation.

10. The method of claim 9 , wherein a portion of the structural support is formed from a radio-opaque material adapted to shield the patient's spinal cord from radiation.

11. The method of claim 7 , wherein the radiation source is configured to provide an asymmetric radiation dose within the tissue surrounding the interstitial space so that radiation sensitive tissue surrounding the interstitial space receives a lesser dose.

12. The method of claim 7 , wherein the radiation source is positioned so as to provide a prescribed absorbed dose of radiation to tissue surrounding the cavity to a predetermined depth.

13. The method of claim 7 , wherein the radiation source comprises at least one solid radiation source disposed on at least one elongate member.

14. The method of claim 7 , wherein a plurality of solid radiation sources are disposed in a spaced apart relationship on a single elongate member.

Assignments (11)
RELEASE OF SECURITY INTEREST Recorded Apr 28, 2026
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: HOLOGIC, INC., ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO BIOLUCENT, LLC; CYTYC SURGICAL PRODUCTS, LLC, AS SUCCESSOR-BY-CONVERSION TO CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; GEN-PROBE INCORPORATED, ON ITS OWN BEHALF AND AS SUCCESSOR-BY-MERGER TO THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.
Reel/Frame 075566/0039 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 035820 FRAME: 0239. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY INTEREST RELEASE. Recorded Nov 9, 2017
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 044727/0529 →
CORRECTIVE ASSIGNMENT TO CORRECT THE INCORRECT PATENT NO. 8081301 PREVIOUSLY RECORDED AT REEL: 028810 FRAME: 0745. ASSIGNOR(S) HEREBY CONFIRMS THE SECURITY AGREEMENT. Recorded Nov 9, 2017
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 044432/0565 →
SECURITY AGREEMENT Recorded Aug 7, 2015
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; DIRECT RADIOGRAPHY CORP.; GEN-PROBE INCORPORATED; GEN-PROBE PRODESSE, INC.; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 036307/0199 →
SECURITY INTEREST RELEASE REEL/FRAME 028810/0745 Recorded Jun 4, 2015
From: GOLDMAN SACHS BANK USA, AS COLLATERAL AGENT
To: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
Reel/Frame 035820/0239 →
SECURITY AGREEMENT Recorded Aug 1, 2012
From: HOLOGIC, INC.; BIOLUCENT, LLC; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS, LIMITED PARTNERSHIP; SUROS SURGICAL SYSTEMS, INC.; THIRD WAVE TECHNOLOGIES, INC.; GEN-PROBE INCORPORATED
To: GOLDMAN SACHS BANK USA
Reel/Frame 028810/0745 →
TERMINATION OF PATENT SECURITY AGREEMENTS AND RELEASE OF SECURITY INTERESTS Recorded Aug 25, 2010
From: GOLDMAN SACHS CREDIT PARTNERS, L.P., AS COLLATERAL AGENT
To: HOLOGIC, INC.; R2 TECHNOLOGY, INC.; SUROS SURGICAL SYSTEMS, INC.; BIOLUCENT, LLC; DIRECT RADIOGRAPHY CORP.; CYTYC CORPORATION; CYTYC SURGICAL PRODUCTS LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS II LIMITED PARTNERSHIP; CYTYC SURGICAL PRODUCTS III, INC.; CYTYC PRENATAL PRODUCTS CORP.; THIRD WAVE TECHNOLOGIES, INC.
Reel/Frame 024944/0315 →
PATENT SECURITY AGREEMENT Recorded Jul 29, 2008
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P., AS COLLATERAL AGENT
Reel/Frame 021301/0879 →
PATENT SECURITY AGREEMENT Recorded Oct 26, 2007
From: CYTYC CORPORATION
To: GOLDMAN SACHS CREDIT PARTNERS L.P.
Reel/Frame 020018/0529 →
MERGER Recorded Nov 21, 2005
From: PROXIMA THEREAPEUTICS, INC.
To: CYTYC CORPORATION
Reel/Frame 017251/0131 →
MERGER, CHANGE OF NAME AND CHANGE OF STATE OF INCORPORATION Recorded Dec 15, 2004
From: PROXIMA THERAPEUTICS, INC. (A MINNESOTA CORPORATION) MERGED WITH AND INTO PTI OF DELAWARE, INC. ( A DELAWARE CORPORATION)
To: PROXIMA THERAPEUTICS, INC.
Reel/Frame 016069/0893 →