Matrix assisted pulsed-laser evaporation technique for coating a medical device and associated system and medical device
A method is provided for coating at least a portion of at least one medical device. The method includes arranging the at least one medical device in a vapor cone and directing a laser at a frozen target. The target includes an agent and the laser vaporizes the agent into the vapor cone. A device is provided for coating at least one medical device. The device includes a target assembly, a laser directed at the target assembly, and an arrangement adapted to hold the at least one medical device in a vapor cone. The vapor cone originates at a target point that a laser beam or a laser pulse contacts a frozen target in the target assembly. A medical device is provided having a coating applied by a method. The method includes arranging the medical device in a vapor cone and directing a laser at a frozen target. The frozen target includes an agent and the laser vaporizes the agent into the vapor cone.
1 . A method for coating at least a portion of at least one medical device, comprising:
directing a laser at a target, the target including a drug and a polymer;
vaporizing by the laser at least a portion of the target into a vapor cone; and
arranging the at least one medical device in the vapor cone.
2 . The method of claim 1 , further comprising dissolving the drug and the polymer in a solvent to prepare a target solution, the target solution forming the target.
3 . The method of claim 2 , further comprising filtering the target solution.
4 . The method of claim 2 , further comprising:
freezing the target solution to make the target; and
mounting the target on a refrigerated rotating assembly.
5 . The method of claim 2 , further comprising:
arranging in a container the target solution in a liquid state to make the target; and
mixing the target solution to maintain a uniform solution of the drug and the polymer in the solvent.
6 . The method of claim 5 , wherein the mixing of the target solution is performed by a stirrer in the container.
7 . The method of claim 5 , wherein the mixing of the target solution is performed by a sonicator in the container.
8 . The method of claim 2 , further comprising:
enclosing the target and the at least one medical device in an evaporation chamber; and
removing by a pump the solvent from the evaporation chamber after the vaporizing operation.
9 . The method of claim 1 , further comprising, after the vaporizing operation, directing a gas flow to transport the drug and the polymer to the at least one medical device.
10 . The method of claim 9 , wherein the gas flow includes an inert gas.
11 . The method of claim 1 , wherein the at least one medical device includes at least one stent.
12 . The method of claim 1 , wherein the laser includes a UV laser.
13 . The method of claim 1 , wherein the laser is pulsed.
14 . The method of claim 1 , further comprising directing at least one of the laser and a second laser at a second target, the second target including at least one of a second drug and a second polymer, the at least one of the laser and the second laser vaporizing the second target into the vapor cone.
15 . A medical device having a coating applied by a method, the method comprising:
directing a laser at a target, the target including a drug and a polymer;
vaporizing by the laser at least a portion of the target into a vapor cone; and
arranging the medical device in the vapor cone.
16 . The medical device of claim 15 , wherein the method further comprises dissolving the drug and the polymer in a solvent to prepare a target solution, the target solution forming the target.
17 . The medical device of claim 15 , wherein the method further comprises: arranging in a container the target solution in a liquid state to make the target; and
mixing the target solution to maintain a uniform solution of the drug and the polymer in the solvent.
18 . The medical device of claim 17 , wherein the mixing of the target solution is performed by a stirrer in the container.
19 . The medical device of claim 17 , wherein the mixing of the target solution is performed by a sonicator in the container.
20 . The medical device of claim 15 , wherein the method further comprises:
enclosing the target and the at least one medical device in an evaporation chamber; and
removing by a pump the solvent from the evaporation chamber after the vaporizing operation.
21 . The medical device of claim 15 , wherein the medical device includes at least one stent.
22 . The medical device of claim 15 , wherein the coating includes a masking material.
23 . The medical device of claim 15 , wherein the coating is chosen from a group consisting of a polymer with a suspended drug, a non-thrombogenic agent, a lubricious material, a non-slippery material, a radioactive agent, and a magnetic signature.
24 . The medical device of claim 15 , wherein the coating is a radiopaque agent.