Synergistic anti-inflammatory pharmaceutical compositions and methods of use
The invention provides a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10. The invention also provides a method of reducing inflammation by administering a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10.
1 . A composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10.
2 . The composition of claim 1 , wherein said isoalpha acid is selected from isohumulone, isocohumulone, and isoadhumulone.
3 . The composition of claim 1 , wherein said reduced isoalpha acid is selected from dihydro-isohumulone, dihydro-isocohumulone, and dihydro-adhumulone.
4 . A method of reducing inflammation, comprising administering a composition comprising a reduced isoalpha acid (RIAA) and isoalpha acid (IAA) isolated from hops, wherein the RIAA and IAA are in a ratio of about 3:1 to about 1:10.
5 . The method of claim 1 , wherein said isoalpha acid is selected from isohumulone, isocohumulone, and isoadhumulone.
6 . The method of claim 1 , wherein said reduced isoalpha acid is selected from dihydro-isohumulone, dihydro-isocohumulone, and dihydro-adhumulone.
7 . A method of reducing inflammation, comprising administering at least two compounds of Genus A having the formula:
wherein R′ is selected from the group consisting of carbonyl, hydroxyl, OR, and OCOR, wherein R is alkyl;
and wherein R″ is selected from the group consisting of CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 , and CH(CH 3 )CH 2 CH 3 , wherein the two compounds are in a ratio of about 10:1 to about 1:10.