Night vision composition
A method for optimizing pupil size in individuals suffering from excessive pupillary dilation in dim light as well as through medication is disclosed. Alpha 1 antagonist is applied in an eye drop formulation to the eye, resulting in reduced pupil size in dim light, but less reduction in pupil size in bright light.
1. An ophthalmic formulation in aqueous solution for topical administration, comprising:
a sterile aqueous carrier including an ophthalmic artificial tear solution; and
a pharmaceutically active compound consisting essentially of phentolamine in a therapeutically effective amount to contract a pupil of a human patient's eye in dim light so that the pupil is effectively reduced by 1.0 mm or more to improve vision in dim light and further to minimize eye redness.
2. The formulation of claim 1 , wherein the pharmaceutically active compound is present in a concentration in a range of from about 0.01 milligrams per cubic centimeter of solvent to about 50 milligrams per cubic centimeter of solvent.
3. The formulation of claim 1 , wherein the pharmaceutically active compound consists essentially of phentolamine in the therapeutically effective amount and in a single dose per day of use so as to contract the pupil of the human patient's eye in dim light so that the pupil is effectively reduced to improve vision in dim light and further to minimize eye redness.
4. An ophthalmic formulation in aqueous solution for topical administration, comprising:
a sterile aqueous carrier including an ophthalmic artificial tear solution; and
a pharmaceutically active compound consisting essentially of phentolamine in a therapeutically effective amount to contract a pupil of a human patient's eye in dim light so that the pupil is effectively reduced to improve vision in dim light and further to minimize eye redness; and
wherein the ophthalmic artificial tear solution includes hydroxypropyl methylcellulose in an amount of about 0.2% to 1.5% by weight of the ophthalmic artificial tear solution.
5. An ophthalmic formulation in aqueous solution for topical administration, comprising:
a sterile aqueous carrier including an ophthalmic artificial tear solution; and
a pharmaceutically active compound consisting essentially of phentolamine in a therapeutically effective amount to contract a pupil of a human patient's eye in dim light from a pupil diameter of 6 mm or greater so that the pupil is effectively reduced to improve vision in dim light and further to minimize eye redness.
6. The formulation of claim 4 , wherein the pharmaceutically active compound is present in a concentration in a range of from about 0.01 milligrams per cubic centimeter of solvent to about 50 milligrams per cubic centimeter of solvent.
7. The formulation of claim 4 , wherein the pharmaceutically active compound is administered in a single dose per day of use.
8. The formulation of claim 4 , wherein the pupil is effectively reduced from a pupil diameter of 6 mm or greater.
9. The formulation of claim 4 , wherein the formulation is administered in an amount so as to optimize pupil diameter in dim light to no more than 5 mm and pupil diameter in bright light is constricted by no more than 1 mm.
10. The formulation of claim 4 , wherein the pupil diameter is effectively reduced to a diameter ranging from about 3 mm to about 5 mm.
11. The formulation of claim 4 , wherein the ophthalmic artificial tear solution comprises at least one of carboxymethylcellulose, polyvinylpyrrolidone, benzalkonium chloride, glycerin, or combinations thereof.
12. The formulation of claim 5 , wherein the pharmaceutically active compound is present in a concentration in a range of from about 0.01 milligrams per cubic centimeter of solvent to about 50 milligrams per cubic centimeter of solvent.
13. The formulation of claim 5 , wherein the pharmaceutically active compound is administered in a single dose per day of use.
14. The formulation of claim 5 , wherein the pupil diameter is effectively reduced to a diameter ranging from about 3 mm to about 5 mm.
15. The formulation of claim 5 , wherein the formulation is administered in an amount so as to optimize pupil diameter in dim light to no more than 5 mm and pupil diameter in bright light is constricted by no more than 1 mm.
16. The formulation of claim 5 , wherein the ophthalmic artificial tear solution comprises at least carboxymethylcellulose, polyvinylpyrrolidone, benzalkonium chloride, glycerin, or combinations thereof.
17. The formulation of claim 1 , wherein the pupil is effectively reduced from a pupil diameter of 6 mm or greater.
18. The formulation of claim 1 , wherein the ophthalmic artificial tear solution includes hydroxypropyl methylcellulose in an amount of about 0.2% to 1.5% by weight of the ophthalmic artificial tear solution.
19. The formulation of claim 1 , wherein the formulation is administered in an amount so as to optimize pupil diameter in dim light to no more than 5 mm and pupil diameter in bright light is constricted by no more than 1 mm.
20. The formulation of claim 1 , wherein the pupil diameter is effectively reduced to a diameter ranging from about 3 mm to about 5 mm.
21. The formulation of claim 1 , wherein the ophthalmic artificial tear solution comprises at least carboxymethylcellulose, polyvinylpyrrolidone, benzalkonium chloride, glycerin, or combinations thereof.