Vinyl sulphone modified polymer
View Patent ↗There is provided a polymer having a side chain of general formula (I) in which R may be any suitable alkyl, oxyalkyl, aryl or oxyaryl linking group R is preferably C 1-6 alkyl (especially —CH 2 —), a benzene group or a group —CH 2 —O-Phe-. Generally, the side chain will be attached to an ethylene moiety forming part of the backbone of the polymer. Preferred polymers include polystyrene. The polymer is useful as a support for solid phase chemical reactions especially combinatorial chemical synthesis.
1. A divinylbenzene cross-linked polystyrene polymer comprising a side chain of formula I:
wherein group R is an alkyl, aryl, oxyalkyl or oxyaryl linker group.
2. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 1 having a backbone comprising an ethylene grouping which is attached to the side chain.
3. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 1 wherein group R is a C 1-10 alkyl or oxyalkyl group.
4. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 3 wherein group R is a C 1-6 alkyl group.
5. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 4 wherein said side chain is of formula II;
wherein ˜ (CH 2 —CH) ˜ is part of the backbone of the polymer.
6. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 1 wherein said side chain is of formula III:
wherein ˜ (CH 2 —CH) ˜ is part of the backbone of the polymer.
7. A divinylbenzene cross-linked polystyrene polymer as claimed in claim 1 in the form of a resin suitable as a support for solid phase chemical reactions.
8. A method of producing a divinylbenzene cross-linked polystyrene polymer as claimed in claim 1 wherein a Merrifield resin is reacted to replace the chlorine atom thereof with a sulphur containing group which is subsequently oxidised to yield a vinyl sulphone moiety of formula I.
9. A method of producing a solid-phase reactant for a solid-phase chemical reaction, said reactant comprising a complex of a substrate moiety and a resin comprising a polymer as claimed in claim 1 , wherein said complex is produced by reacting a precursor substrate with a functional group on the resin.
10. A method of chemical synthesis involving a chemical reaction wherein one of the substrates of said reaction is in the form of a solid-phase complex with a resin comprising a polymer as claimed in claim 1 .
11. A microreactor comprising a resin material as a support matrix for a solid-phase chemical reaction, wherein said main material Comprises a polymer as claimed in claim 1 .