Compositions for vaginal treatment
View Patent ↗The invention provides mannose phosphate and salts thereof for increasing vaginal cell growth, vaginal cell maturation and vaginal moisture, as well as compositions, articles and methods for treating and preventing vaginal conditions characterized by poor vaginal cell growth, low vaginal cell differentiation and low vaginal moisture.
1. A method for treating vaginal atrophy, promoting vaginal epithelial cell proliferation and/or promoting vaginal epithelial cell differentiation in a patient in need thereof, comprising intravaginally administering to the patient an effective amount of a composition comprising mannose phosphate or a salt thereof, wherein the mannose phosphate or salt thereof can increase growth of mammalian epithelial cells.
2. The method of claim 1 , wherein the vaginal atrophy comprises low vaginal moisture.
3. The method of claim 1 , wherein the composition can increase production of glycogen by vaginal epithelial cells.
4. The method of claim 1 , wherein the mannose phosphate is mannose-6-phosphate.
5. The method of claim 1 , wherein the mannose phosphate is a compound of the formula:
wherein X is a monovalent or divalent cation.
6. The method of claim 1 , wherein the mannose phosphate is mixed with or covalently linked to a polymer.
7. The method of claim 6 , wherein the polymer is poly(ethylene glycol), poly(vinyl alcohol), poly(vinylpyrrolidone), or poly(2-hydroxylethyl methacrylate).
8. The method of claim 1 , wherein the effective amount comprises about 0.001 micrograms to about 500 milligrams of mannose phosphate or salt thereof.
9. The method of claim 1 , wherein the composition further comprises an anti-bacterial, anti-fungal or anti-viral agent.
10. The method of claim 1 , wherein the composition further comprises hyaluronic acid.
11. The method of claim 1 , wherein the composition is a lotion, cream, gel or suspension.