Chemically stable compositions of 4-hydroxy tamoxifen
A class of chemically stable 4-hydroxy tamoxifen compositions is characterized by roughly equal amounts of the Z-4-hydroxy tamoxifen and E-4-hydroxy tamoxifen isomers, such that the potency of the compositions is not affected adversely by the isomerization that occurs between these two forms. The inventive compositions are useful for preventing or for treating medical conditions.
1 . A pharmaceutical composition at the equilibrium state that comprises 4-hydroxy tamoxifen, wherein about 45%-55%, about 46%-54%, about 47%-53%, about 48%-52%, about 49%-51% or about 50% of said 4-hydroxy tamoxifen exists in a Z isomeric form and the remainder of said 4-hydroxy tamoxifen exists in an E isomeric form.
2 . The pharmaceutical composition of claim 1 , wherein about 48%-52% of said 4-hydroxy tamoxifen exists in a Z isomeric form and the remainder of said 4-hydroxy tamoxifen exists in an E isomeric form.
3 . The pharmaceutical composition of 1, wherein about 50% of said 4-hydroxy tamoxifen exists in a Z isomeric form and the remainder of said 4-hydroxy tamoxifen exists in an E isomeric form.
4 . The pharmaceutical composition of claim 1 , which is formulated for percutaneous administration.
5 . The pharmaceutical composition of claim 4 , which further comprises an alcohol.
6 . The pharmaceutical composition of claim 4 , which further comprises a penetration enhancer.
7 . The pharmaceutical composition of claim 4 , wherein said 4-hydroxy tamoxifen is formulated in a hydroalcoholic gel, a hydroalcoholic solution, a patch, an ointment, a cream, an emulsion (lotion), a powder or an oil.
8 . The pharmaceutical composition of claim 7 , wherein said 4-hydroxy tamoxifen is formulated in a hydroalcoholic gel.
9 . The pharmaceutical composition of claim 8 , wherein said hydroalcoholic gel comprises ethyl alcohol, isopropyl myristate, and hydroxypropylcellulose.
10 . The pharmaceutical composition of claim 7 , wherein said 4-hydroxy tamoxifen is formulated in a hydroalcoholic solution.
11 . The pharmaceutical composition of claim 4 , which is a hydroalcoholic composition further comprising a penetration enhancer, an aqueous vehicle, an alcoholic vehicle and a gelling agent.
12 . The pharmaceutical composition of claim 11 , which further comprises a neutralizing agent.
13 . The pharmaceutical composition of claim 11 , wherein the penetration enhancer comprises at least a fatty acid ester.
14 . The pharmaceutical composition of claim 11 , wherein said pharmaceutical composition comprises:
a) about 0.01% to 0.2% by weight of 4-hydroxy tamoxifen,
b) about 0.5% to 2% by weight of isopropyl myristate,
c) about 60% to 75% by weight of absolute alcohol,
d) about 25% to 40% by weight of aqueous vehicle,
e) about 0.5% to 5% by weight of gelling agent,
wherein the percentage of components are weight to weight of the composition.
15 . The pharmaceutical composition of claim 14 , wherein the 4-hydroxy tamoxifen constitutes about 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.10%, 0.11%, 0.12%, 0.13%, 0.14%, 0.15%, 0.16%, 0.17%, 0.18%, 0.19% or 0.20% by weight of the composition.
16 . The pharmaceutical composition of claim 14 , wherein the isopropyl myristate constitutes about 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9% or 2.0% by weight of the composition.
17 . The pharmaceutical composition of claim 14 , wherein the alcohol is ethanol or isopropanol, and constitutes about 60 to 75% by weight of the composition.
18 . The pharmaceutical composition of claim 14 , wherein the aqueous vehicle is a phosphate buffered solution, and constitutes about 25% to 40% by weight of the composition.
19 . The pharmaceutical composition of claim 14 , wherein the aqueous vehicle is a phosphate buffered solution, and the pH of said pharmaceutical composition is about 4 to about 12, about 6 to about 11, about 8 to about 10, or about 9.
20 . The pharmaceutical composition of claim 14 , wherein the gelling agent is a polyacrylic acid, hydroxypropylcellulose or other cellulose derivative, and constitutes about 0.5% to 5% by weight of the composition.
21 . The pharmaceutical composition of claim 14 , which further comprises a neutralizing agent selected in the group consisting of sodium hydroxide, ammonium hydroxide, potassium hydroxide, arginine, aminomethylpropanol and tromethamine, which neutralizing agent exists at a neutralizing agent/gelling agent ratio between about 4:1 and 1:1.
22 . The pharmaceutical composition of claim 14 , which is packaged in a unit dose packet or in a multiple dose container with a metered pump.