Microfluidic device including displaceable material trap, and system
View Patent ↗A microfluidic device is provided that can include at least one trap for receiving displaceable adhesion material displaced during a closing operation of a deformable valve. The trap can be formed as a recess or chamber in a substrate of the microfluidic device. A system including a deformer for opening such a valve is also provided as are methods of opening such a valve.
1. A device comprising:
a first liquid-containment feature having a first depth;
a second liquid-containment feature having a second depth;
a deformable valve separating the first liquid-containment feature from the second liquid-containment feature and capable of being opened to provide a fluid communication between the first liquid-containment feature and the second liquid-containment feature, the deformable valve including a substrate, a cover layer, and a displaceable adhesion material between the substrate and the cover layer; and
a recess arranged adjacent the deformable valve, adjacent the first liquid-containment feature, having a third depth and being capable of receiving the displaceable adhesion material upon opening of the deformable valve.
2. The device of claim 1 , wherein the third depth is less than the first depth.
3. The device of claim 1 , further comprising a second recess adjacent the deformable valve, adjacent the second liquid-containment feature, having a fourth depth and being capable of receiving the displaceable adhesion material upon opening of the deformable valve.
4. The device of claim 3 , wherein the fourth depth is less than the second depth.
5. The device of claim 3 , wherein the third depth and the fourth depth are the same depth.
6. The device of claim 1 , wherein the displaceable adhesion material is at least one of a resin, glue, adhesive, epoxy, silicone, urethane, wax, isocyanate, pressure sensitive adhesive, hot melt adhesive, or a combination thereof.
7. The device of claim 1 , wherein the displaceable adhesion material is a hot melt adhesive.
8. The device of claim 1 , wherein the third depth is from about five percent to about 30 percent of the first depth.
9. The device of claim 1 , wherein the deformable valve is in an open state and comprises a fluid communication between the first liquid-containment feature and the second liquid-containment feature, the fluid communication has a first width, the recess has a second width, and the first width is from about two percent to about 50 percent the second width.
10. The device of claim 9 , wherein the first width is from about five percent to about 20 percent of the second width.
11. A device comprising:
a substrate including;
a first surface,
a first liquid-containment feature formed in the first surface,
a second liquid-containment feature formed in the first surface,
an intermediate wall at least partially defined by the first surface and separating the first liquid-containment feature from the second liquid-containment feature, and
a trap recessed in relation to the first surface of the substrate and arranged adjacent the intermediate wall;
an elastically deformable cover sheet; and
a layer of displaceable adhesion material applied to at least a portion of a side of the cover sheet;
wherein the cover sheet is adhered to the first surface of the substrate at, at least the intermediate wall when the cover sheet is in a non-deformed state.
12. The device of claim 11 , wherein the trap extends from at least one of the first and second liquid-containment features to the intermediate wall.
13. The device of claim 11 , wherein the trap is capable of receiving displaced adhesion material from the layer of displaceable adhesion material when the intermediate wall is deformed.
14. The device of claim 11 , further comprising a second trap that is recessed in relation to the first surface of the substrate and arranged adjacent to the intermediate wall.
15. The device of claim 11 , wherein the device comprises a microfluidic device.
16. The device of claim. 11 , wherein the displaceable adhesion material comprises at least one of a resin, glue, adhesive, epoxy, silicone, urethane, wax, plastic, polyolefin, polymer, isocyanate, pressure sensitive adhesive, hot melt adhesive, or combination thereof
17. The device of claim 11 , wherein the displaceable adhesion material comprises a hot melt adhesive.
18. A system comprising:
a microfluidic device comprising:
a first liquid-containment feature;
a second liquid-containment feature;
a deformable valve separating the first liquid-containment feature from the second liquid-containment feature and being capable of selectively controlling a fluid communication between the first liquid-containment feature and the second liquid-containment feature, the deformable valve including a substrate and a cover layer, the cover layer being attached to the substrate by way of a layer of displaceable adhesion material; and
a trap adjacent the deformable valve and capable of receiving at least a portion of the displaceable adhesion material that is displaced upon actuation of the deformable valve;
a platen including at least one holder for holding the microfluidic device;
a first deformer; and
a drive unit capable of driving the first deformer toward the microfluidic device while the microfluidic device is positioned in the holder, and capable of applying a deforming force to the cover sheet and the substrate to displace the adhesion material from the displaceable adhesion material layer and into the trap.
19. The system of claim 18 , wherein the drive unit is capable of moving the first deformer out of contact with the cover layer, and the cover layer is capable of elastically rebounding from a deformed state faster than the substrate to form a fluid communication between the first and second liquid-containment features.
20. The system of claim 18 , wherein the displaceable adhesion material comprises at least one of a resin, glue, adhesive, epoxy, silicone, urethane, wax, plastic, polyolefin, polymer, isocyanate, pressure sensitive adhesive, hot melt adhesive, or combination thereof
21. The system of claim 18 , wherein the displaceable adhesion material comprises a hot melt adhesive.
22. A method of actuating a deformable valve, comprising:
providing a microfluidic device, the microfluidic device comprising first and second liquid-containment features, a deformable valve capable of selectively controlling fluid communication between the first liquid-containment feature and the second liquid-containment feature, and a trap recessed with respect to, and adjacent the deformable valve, the deformable valve including a substrate, a cover layer, and a layer of displaceable adhesion material disposed in contact with and between the substrate and the cover layer;
deforming the cover layer and the substrate, with a deformer; and
forcing displaceable adhesion material displaced from the layer of displaceable adhesion material, into the trap.
23. The method of claim 22 , further comprising: retracting the deformer from contact with the cover layer; and forming a fluid communication opening between the first and second liquid-containment features.
24. The method of claim 23 , further comprising:
forcing a second deformer into contact with the cover layer across an area corresponding to a width of the fluid communication opening; and
displacing adhesion material into the fluid communication opening to close the fluid communication between the first and second liquid-containment features.