Isolated monkey cathepsin S proteins, nucleic acid molecules encoding monkey cathepsin S proteins, and uses thereof
View Patent ↗The present invention provides isolated monkey Cathepsin S proteins and isolated nucleic acid molecules such as cDNA molecules that encode these monkey Cathepsin S proteins. The present invention specifically provides, for example, isolated monkey Cathepsin S proteins and encoding nucleic acid molecules, methods of producing the monkey Cathepsin S proteins, methods of identifying and screening modulators of the monkey Cathepsin S proteins, and methods of using these modulators to treat a human disease or disorders associated with an orthologous human Cathepsin S protein.
1. An isolated polypeptide, wherein the amino acid sequence of the polypeptide consists of SEQ ID NO:2.
2. An isolated polypeptide, wherein the amino acid sequence of the polypeptide comprises SEQ ID NO:2.
3. An isolated polypeptide, wherein the amino acid sequence of said polypeptide consists of an amino sequence having at least 99% sequence identity to SEQ ID NO:2.
4. An isolated polypeptide, wherein the amino acid sequence of said polypeptide comprises an amino acid sequence having at least 99% sequence identity to SEQ ID NO:2.
5. A fusion polypeptide, wherein the fusion polypeptide comprises the polypeptide of claim 2 fused to a heterologous amino add sequence.
6. A fusion polypeptide, wherein the fusion polypeptide comprises the polypeptide of claim 4 fused to a heterologous amino acid sequence.
7. A composition comprising the polypeptide of claim 1 .
8. A composition comprising the polypeptide of claim 2 .
9. A composition comprising the polypeptide of claim 3 .
10. A composition comprising the polypeptide of claim 4 .
11. A composition comprising the polypeptide of claim 5 .
12. A composition comprising the polypeptide of claim 6 .