Compositions and methods for treating coronavirus infection and SARS
The present invention provides methods of treating a coronavirus infection, and methods of reducing viral load, or reducing the time to viral clearance, or reducing morbidity or mortality in the clinical outcomes, in patients suffering from a coronavirus infection. The present invention further provides methods of reducing the risk that an individual will develop a pathological coronavirus infection, that has clinical sequelae. The present invention further provides methods of reducing the risk that an individual will develop SARS. The present invention further provides methods of treating SARS. The methods generally involve administering a therapeutically effective amount of a Type I or Type III interferon receptor agonist and/or a Type II interferon receptor agonist for the treatment of a coronavirus infection.
1 . A method of treating a coronavirus infection, the method comprising administering to an individual an effective amount of IFN-α.
2 . The method of claim 1 , wherein the individual has been exposed to a coronavirus, and the IFN-α is administered within 24 hours of exposure to the coronavirus.
3 . The method of claim 1 , wherein the individual has been exposed to a coronavirus, and the IFN-α is administered within 48 hours of exposure to the coronavirus.
4 . The method of claim 1 , wherein the individual has been exposed to a coronavirus, and the IFN-α is administered 72 hours to 35 days after exposure to the coronavirus.
5 . A method of treating a coronavirus infection, the method comprising administering to an individual an effective amount of IFN-γ.
6 . The method of claim 5 , wherein the individual has been exposed to a coronavirus, and the IFN-γ is administered within 24 hours of exposure to the coronavirus.
7 . The method of claim 5 , wherein the individual has been exposed to a coronavirus, and the IFN-γ is administered within 48 hours of exposure to the coronavirus.
8 . The method of claim 5 , wherein the individual has been exposed to a coronavirus, and the IFN-γ is administered 72 hours to 35 days after exposure to the coronavirus.
9 . A method of treating a coronavirus infection, the method comprising administering to an individual an effective amount of IFN-γ and an effective amount of IFN-α.
10 . The method of claim 9 , wherein the individual has been exposed to a coronavirus, and the IFN-γ and the IFN-α are administered within 24 hours of exposure to the coronavirus.
11 . The method of claim 9 , wherein the individual has been exposed to a coronavirus, and the IFN-γ and the IFN-α are administered within 48 hours of exposure to the coronavirus.
12 . The method of claim 9 , wherein the individual has been exposed to a coronavirus, and the IFN-γ and the IFN-α are administered 72 hours to 35 days after exposure to the coronavirus.
13 . The method of claim 9 , wherein the IFN-α and the IFN-γ are administered subcutaneously.
14 . A method of treating severe acute respiratory syndrome (SARS) in an individual, the method comprising administering an effective amount of IFN-α to the individual
15 . The method of claim 14 , wherein the IFN-α is administered within 24 hours of the appearance of a symptom of SARS in the individual.
16 . The method of claim 14 , wherein the IFN-α is administered within 48 hours of the appearance of a symptom of SARS in the individual.
17 . A method of treating severe acute respiratory syndrome (SARS) in an individual, the method comprising administering an effective amount of IFN-γ to the individual
18 . The method of claim 17 , wherein the IFN-γ is administered within 24 hours of the appearance of a symptom of SARS in the individual.
19 . The method of claim 17 , wherein the IFN-γ is administered within 48 hours of the appearance of a symptom of SARS in the individual.
20 . A method of treating severe acute respiratory syndrome (SARS) in an individual, the method comprising administering an effective amount of IFN-α and an effective amount of IFN-γ to the individual.
21 . The method of claim 20 , wherein the IFN-α and the IFN-γ are administered within 24 hours of the appearance of a symptom of SARS in the individual.
22 . The method of claim 20 , wherein the IFN-α and the IFN-γ are administered within 48 hours of the appearance of a symptom of SARS in the individual.
23 . A method of reducing the risk that an individual will develop severe acute respiratory syndrome (SARS), the method comprising administering to the individual an effective amount of IFN-α.
24 . A method of reducing the risk that an individual will develop severe acute respiratory syndrome (SARS), the method comprising administering to the individual an effective amount of IFN-γ.
25 . A method of reducing the risk that an individual will develop severe acute respiratory syndrome (SARS), the method comprising administering to the individual an effective amount of IFN-α and an effective amount of IFN-γ.
26 . The method of any one of claims 1 , 5 , 9 , 14 , 17 , 20 , and 23 - 25 , further comprising administering an effective amount of a nucleotide analog or a nucleoside analog.
27 . The method of any one of claims 1 , 5 , 9 , 14 , 17 , 20 , and 23 - 25 , further comprising administering an effective amount of ribavirin.
28 . The method of any one of claims 1 - 4 , 9 - 13 , 14 - 16 , 20 - 23 , and 25 , wherein the IFN-α is a consensus interferon.