Disposable mixing system
View Patent ↗The present invention uses one or more bags that are capable of being selectively pressurized and deflated in conjunction with a disposable bio bag such as a fermenter, mixing bag, storage bag and the like. The pressure bag(s) may surround a selected outer portion of the bag or may be contained within an inner portion of such a bag. By selectively pressurizing and deflating the pressure bag(s), one is able to achieve fluid motion in the bag thereby ensuring cell suspension, mixing and gas transfer within the bag without damaging shear forces or foam generation.
1. A mixing device consisting essentially of a mixing bag having an inner volume, the inner volume containing a liquid to mixed, one or more pressure bags being in a position selected from the group consisting of below and around the mixing bag, each of the one or more pressure bags having an inlet, each of the one or more pressure bags having an outlet, the inlet of the one or more pressure bags being connected to a source of pressurized gas and being capable of being selectively opened and closed so as to inflate and deflate the one or more pressure bags as desired.
2. The device of claim 1 wherein the one or more pressure bags are adjacent an outside portion of the mixing bag and are secured to the mixing bag.
3. The device of claim 1 wherein the one or more pressure bags are one in number and is adjacent an outside portion of the mixing bag at a central location.
4. The device of claim 1 wherein the inlet and/or outlet of each of the one or more pressure bags is selectively opened and closed through one or more valves adjacent the inlet and/or outlet of each of the one or more pressure bags.
5. A system for the mixing of components consisting essentially of a mixing bag having a volume for containing the components to be mixed, one or more components, at least one of the one or more components being in liquid form, the mixing bag having an inlet and an outlet, the inlet and outlet being capable of being selectively opened and closed, one or more pressure bags being positioned adjacent the mixing bag, the one or more pressure bags being in a position selected from the group consisting of below and around the mixing bag, each of the one or more pressure bags having an inlet, and each of the one or more pressure bags having an outlet, the inlet of the pressure bag being connected to a source of pressurized gas and a control unit connected to at least the pressure bag inlet to control the selective opening and closing of the inlet.
6. The system of claim 5 wherein each inlet to each of the one or more pressure bags has a valve actuated by the control unit to control the selective opening and closing of each inlet.
7. A method for the mixing of components consisting essentially of a mixing bag having an inner volume, the volume containing two or more constituents to be mixed, at least one of the two or more constituents being a liquid, providing one or more pressure bags positioned adjacent the mixing bag, the pressure bags being in a position selected from the group consisting of below and around the mixing bag, each of the one or more pressure bags having an inlet, each of the one or more pressure bags having an outlet, the inlet and outlet being capable of being selectively opened and closed, the inlet of the one or more pressure bags being connected to a source of pressurized gas, closing the outlet to at least one of the one or more pressure bags and selectively applying the pressurized gas to the inlet of at least one of the one or more pressure bags so as to inflate at least one of the one or more pressure bags, selectively stopping the supply of pressurized gas to the at least one of the one or more pressure bags by closing the inlet of the at least one of the one or more pressure bags to create a wave motion of the constituents within the volume and opening the outlet to at least one of the one or more pressure bags to deflate the at least one of the one or more pressure bags.
8. A mixing device consisting essentially of a mixing bag having an inner volume, the inner volume containing a liquid to mixed, the mixing bag having a first end, a second end and a middle, one or more pressure bags positioned adjacent the first end of the mixing bag, the one or more pressure bags being in a position selected from the group consisting of below and around the mixing bag, each of the one or more pressure bags having an inlet, and each of the one or more pressure bags having an outlet, the inlet and outlet being capable of being selectively opened and closed, the inlet of the one or more pressure bags being connected to a source of pressurized gas and being capable of being selectively opened and closed so as to inflate and deflate the one or more pressure bags as desired.
9. The device of claim 8 wherein there is one pressure bag, it is located at the first end of the mixing bag and it is in a position below the mixing bag.
10. The device of claim 8 wherein there is one pressure bag, it is located at the middle of the mixing bag and it is in a position around the mixing bag.