Cetylpyridinium chloride as an antimicrobial agent in ophthalmic compositions
View Patent ↗A multi-purpose contact lens care solution having high antimicrobial activity comprising, in an aqueous liquid medium, cetylpyridinium chloride and a non-ionic surfactant. In one embodiment of the invention, the non-ionic surfactant is a poly(oxypropylene)-poly(oxyethylene) block copolymer. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and/or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.
1. A multi-purpose solution comprising:
an aqueous liquid medium; about 0.1 ppm to about 9.5 ppm cetylpyridinium chloride; and
a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution.
2. The solution as in claim 1 , wherein the solution comprises about 0.5 ppm to about 9 ppm cetylpyridinium chloride.
3. The solution as in claim 1 , further comprising a second antimicrobial component.
4. The solution as in claim 1 , further comprising a viscosity inducing component selected from the group consisting of cellulosic derivatives and mixtures thereof in the range of about 0.05% to about 5.0% (w/v) of the total solution.
5. The solution as in claim 1 , further comprising a buffer component in an amount effective in maintaining the pH of said solution within a physiologically acceptable range.
6. The solution as in claim 1 , wherein the buffer is selected from the group consisting of boric acid/sodium hydroxide buffers and boric acid/sodium borate buffers.
7. A multi-purpose solution for contact lens care comprising:
an aqueous liquid medium;
about 0.1 ppm to about 9.5 ppm cetylpyridinium chloride;
a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution;
a buffer component in an amount effective in maintaining the pH of said solution within a physiologically acceptable range;
a viscosity inducing component selected from the group consisting of cellulosic derivatives and mixtures thereof;
a chelating component; and a tonicity component in an amount effective in providing the desired tonicity to said solution.
8. The multi-purpose solution of claim 7 , further comprising a second antimicrobial component.
9. The multi-purpose solution of claim 7 , wherein the second antimicrobial component is present in an amount ranging from about 0.1 ppm to about 3 ppm.
10. The multi-purpose solution of claim 7 , wherein the poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant is present in an amount in a range of about 0.01% to about 1.0% (w/v).
11. The multi-purpose solution of claim 7 , wherein the buffer component includes boric acid.
12. The multi-purpose solution of claim 7 , further comprising taurine.
13. A multi-purpose solution comprising:
an aqueous liquid medium; about 0.1 to about 9.5 ppm of cetylpyridinium chloride;
a second antimicrobial agent;
a poly(oxypropylene)-poly(oxyethylene) block copolymer surfactant in an amount effective in cleaning a contact lens contacted with said solution; and taurine in an amount effective to protect ocular tissue cell membranes.