IP Library › Granted Patent US 7,169,390
Granted Patent B2
US 7,169,390 · App. 10/820,582 · Granted Jan 30, 2007

Compositions and methods for the treatment and prevention of cancer, angiogenesis, and inflammation

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,169,390
App. No.
10/820,582
Granted
Jan 30, 2007
Kind
B2
Abstract

Methods and compositions are disclosed that are useful for the prevention and/or treatment of cancer, angiogenesis, and inflammation. The beneficial effects of the compositions and methods are achieved through the use of pharmaceutical compositions that include agents that bind spingolipids or sphingolipid metabolites. In one embodiment the agent is an antibody or antibody derivative. In some embodiments, the agent is a receptor of a sphingolipid or a sphingolipid metabolite. Also disclosed are methods for identifying and isolating therapeutic agents.

Claims (2)

1. A method for treating cancer in a patient comprising administering to the patient an agent the specifically binds to sphingosine-1-phosphate (S-1-P) in an amount effective to reduce the available concentration of S-1-P in the patient, whereby the agent treats the cancer.

2. The method according to claim 1 , wherein said agent is an antibody or an antibody derivative that specifically binds to the S-1-P.

Assignments (9)
RELEASE OF SECURITY INTEREST Recorded Dec 30, 2021
From: SLR INVESTMENT CORP. (F/K/A SOLAR CAPITAL LTD.)
To: APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; APOLLO ENDOSURGERY, INC.; LPATH THERAPEUTICS INC.
Reel/Frame 058599/0297 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 15, 2019
From: APOLLO ENDOSURGERY, INC.
To: SOLAR CAPITAL LTD., AS COLLATERAL AGENT
Reel/Frame 048885/0621 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 048622/0358 →
CHANGE OF NAME Recorded Mar 27, 2017
From: LPATH, INC.
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 042097/0896 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0766 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 30, 2014
From: SABBADINI, ROGER A.
To: MEDLYTE, INC.
Reel/Frame 033423/0937 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 25, 2014
From: LPATH THERAPEUTICS, INC.
To: LPATH, INC.
Reel/Frame 033396/0609 →
CHANGE OF NAME Recorded Oct 13, 2006
From: MEDLYTE, INC.
To: LPATH THERAPEUTICS, INC.
Reel/Frame 018395/0090 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 18, 2004
From: SABBADINI, ROGER A.
To: MEDLYTE, INC.
Reel/Frame 015072/0964 →