IP Library › Granted Patent US 7,317,091
Granted Patent B2
US 7,317,091 · App. 10/822,231 · Granted Jan 8, 2008

Optimized Fc variants

Assignee: Xencor, Inc.
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Quick Facts
Patent No.
US 7,317,091
App. No.
10/822,231
Granted
Jan 8, 2008
Kind
B2
Abstract

The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

Claims (1)

1. An antibody or an immunoadhesin of a parent Fc polypeptide, said antibody or immunoadhesin comprising an amino acid modification at position 332 in the Fc region of said parent Fc polypeptide, wherein said antibody or immunoadhesin exhibits altered binding to an FcγR as compared to said parent Fc polypeptide, wherein numbering is according to the EU index.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 10, 2004
From: LAZAR, GREGORY ALAN; CHIRINO, ARTHUR J.; DANG, WEI; DESJARLAIS, JOHN R.; DOBERSTEIN, STEPHEN KOHL; HAYES, ROBERT J.; KARKI, SHER BAHADUR; VAFA, OMID
To: XENCOR, INC.
Reel/Frame 015970/0065 →
Continuity (10)
Continuation In Part 1067228000 · Sep 26, 2003
Continuation In Part 1037939200 · Mar 3, 2003
Provisional Application 6047783900 · Jun 12, 2003
Provisional Application 6046760600 · May 2, 2003
Provisional Application 6044230100 · Jan 23, 2003
Provisional Application 6041443300 · Sep 27, 2002
Provisional Application 6038419700 · May 29, 2002
Provisional Application 6036084300 · Mar 1, 2002
Related Publication 20050054832A1 · Mar 10, 2005
Related Publication 20060160996A9 · Jul 20, 2006