Compositions comprising phenylaminothiophenacetic acid derivatives for the treatment of acute or adult respiratory distress syndrome (ARDS) and infant respiratory distress syndrome (IRDS)
View Patent ↗Novel compositions for the treatment of IRDS and ARDS are indicated which contain a compound of formula (I), in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound and lung surfactant
1. A composition for the treatment of Infant Respiratory Distress Syndrome (IRDS) or Adult Respiratory Distress Syndrome (ARDS) comprising
a) a compound of formula I
in which R1 is hydrogen or 2-(2-hydroxyethoxy)ethyl and/or a pharmacologically tolerable salt of this compound;
b) lung surfactant comprising a mixture of phospholipids; and
c) lung surfactant protein, wherein the lung surfactant protein is a recombinant SP-C derivative which differs from human SP-C by replacement of the two cysteines (in positions 4 and 5) by phenylalanine and replacement of the methionine in position 32 by isoleucine.
2. The composition as claimed in claim 1 in powder form.
3. The method of treating a patient afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 1 .
4. A method of elevating the arterial oxygen partial pressure in patients afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 1 .
5. A method to minimize the formation of hyaline membranes in lungs of a patient afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 1 .
6. A composition as claimed in claim 1 for the treatment of IRDS and ARDS wherein the phospholipids are those which occur in natural lung surfactant.
7. The composition as claimed in claim 6 in powder form.
8. The method of treating a patient afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 6 .
9. A method of elevating the arterial oxygen partial pressure in a patient afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 6 .
10. A method to minimize the formation of hyaline membranes in lungs of a patient afflicted with IRDS or ARDS, which comprises administering to said patient an effective amount of a composition as claimed in claim 6 .