System with a sensor for perfusion management

1 . A device for perfusion management, comprising:

a body portion;

at least one extensible finger coupled to said body portion;

control circuitry coupled to said extensible finger or said body portion; and

at least one sensor coupled to said extensible finger.

2 . The device according to claim 1 , further comprising a pump, or a source of pressure coupled to said body portion or said at least one extensible finger.

3 . The device according to claim 1 , further comprising a motor, or an actuator coupled to said at least one extensible finger.

4 . The device according to claim 1 , further comprising an operative tool carried by at least one extensible finger.

5 . The device according to claim 4 , further comprising a tool positioner carried by at least one extensible finger.

6 . The device according to claim 4 , wherein said operative tool comprises a device for ablating, degrading, or liquefying a cell, a mass of cells, a tissue, or an assembly of biological materials exhibiting shear strength.

7 . The device according to claim 4 , wherein said control circuitry is operative to guide said operative tool.

8 . The device according to claim 1 , further comprising a source of an electric charge or an electromagnetic radiation coupled to said extensible finger in proximity to a location.

9 . The device according to claim 1 , further comprising a device for removing a cell, a tissue, a fluid, a gel, a colloid, an emulsion, a sample, a contaminant, a debris, or a biological material coupled to said at least one extensible finger.

10 . The device according to claim 1 , wherein said at least one extensible finger includes a plurality of extending parts.

11 . The device according to claim 10 , wherein said at least one plurality of extending parts is hollow.

12 . The device according to claim 1 , wherein said extensible finger is coupled to a device for fully or partially blocking or shunting a liquid flow.

13 . The device according to claim 1 , comprising a siphon, a vacuum, or an evacuation device coupled to said extensible finger.

14 . The device according to claim 1 , comprising a source of an electric charge or electromagnetic radiation coupled to said extensible finger.

15 . The device according to claim 1 , comprising a device to cauterize or seal a cell, a mass of cells, a tissue, or an assembly of biological materials exhibiting shear strength coupled to said extensible finger.

16 . The device according to claim 1 , comprising a stent coupled to said extensible finger.

17 . The device according to claim 1 , wherein said extensible finger is coated with a polymer or a biocompatible material.

18 . The device according to claim 1 , further comprising a fluid dispenser operative to provide a fluid at a controlled rate.

19 . The device according to claim 18 , wherein said fluid dispenser is carried by said at least one extensible finger.

20 . The device according to claim 1 , comprising a receptacle operative for storing a receivable.

21 . The device according to claim 20 , wherein said receptacle is carried by or coupled to said extensible finger.

22 . The device according to claim 20 or 21 , wherein said receptacle is coupled to said control circuitry.

23 . The device according to claim 1 , wherein said at least one extensible finger is coupled to a source of a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction internal or external to said device.

24 . The device according to claim 1 , wherein said at least one extensible finger is coupled to a source of two or more of a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction internal or external to said device.

25 . The device according to claim 1 , further comprising a data transmitter, coupled to said sensor or said control circuit.

26 . The device according to claim 1 , further comprising a data receiver coupled to said sensor or said control circuit.

27 . The device according to claim 25 or 26 , wherein said device communicates exterior to said animal.

28 . The device according to claim 25 , wherein said device is configured for monitoring or controlling by a person external to said animal.

29 . The device for perfusion management according to claim 1 , wherein said device is operative to provide a treatment or to monitor a response in said animal.

30 . The device for perfusion management according to claim 29 , wherein said treatment comprises delivering a medicinal agent, a pharmaceutical agent, a therapeutic device or assembly to a location in said animal.

31 . The device for perfusion management according to claim 1 , wherein said control circuitry comprises a processor, a feedback circuit, or a logic circuit.

32 . The device for perfusion management according to claim 1 , wherein said control circuitry is a processor further comprising a stored software or firmware program cooperative with said processor.

33 . The device according to claim 1 , wherein said control circuitry guides or moves said at least one extensible finger.

34 . The device according to claim 1 , wherein said at least one sensor comprises an imager, a pressure sensor, a temperature sensor, a chemical sensor, a gas sensor, an electrolyte sensor, a composition sensor, a concentration sensor, or a flow sensor.

35 . The device according to claim 1 , wherein said device is of a size, composition, power dissipation level, or shape configured for full or partial placement in vivo.

36 . The device according to claim 1 , wherein said device is coupled wirelessly for monitoring or controlling.

37 . The device according to claim 1 , wherein said device configured for implantation in said animal is of a dimension, a composition, a power dissipation level, or a shape appropriate for implantation in a selected location.

38 . The device for perfusion management according to claim 37 , wherein said selected location is in a circulatory system, an aorta, or a vena cava.

39 . A method for fabricating a perfusion management device, comprising:

forming an elongating member for placement in proximity to a target location within an animal;

coupling a signal detector for tracking a signal from said target location within said animal; and

providing a positioning system communicating with said elongating member or said signal detector, said positioning system including logic or software configured for moving said elongating member to a second location cooperative with said signal from said target location.

40 . The method according to claim 39 , further comprising the step of coating said elongating member with a polymer or a biocompatible material.

41 . The method according to claim 39 , further comprising coupling a cavity to said elongating member for storing a receivable.

42 . The method according to claim 41 , comprising the step of coupling said cavity to a mixing cavity.

43 . The method according to claim 41 or 42 , including coupling a source of a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger a molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction internal or external to said cavity.

44 . The method according to claim 41 or 42 , including coupling a source of two or more of a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger a molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction internal or external to said cavity.

45 . The method according to claim 39 , comprising the step of coupling a device for partially blocking or shunting a liquid flow to said device.

46 . The method according to claim 39 , wherein a fluid dispenser is carried by said elongating member, said fluid dispenser including a fluid controller operative to provide a fluid at a controlled rate.

47 . The method according to claim 39 , comprising the step of coupling a motor or an actuator to said elongating member.

48 . The method according to claim 39 , comprising the step of coupling a source of an electric charge or an electromagnetic radiation to said elongating member.

49 . The method according to claim 39 , comprising the step of configuring said device to be monitored or controlled by a person.

50 . The method according to claim 39 , comprising the step of configuring said device for implantation in said predetermined location in said animal.

51 . The method according to claim 39 , including coupling a device for data gathering, processing, storage or transmission to positioning system.

52 . The method according to claim 39 , wherein said positioning system communicates wirelessly.

53 . The method according to claim 39 , wherein said positioning system is operative for guiding or moving said elongating member.

54 . The method according to claim 39 , wherein said positioning system comprises a processor, a feedback circuit, or a logic circuit.

55 . The method according to claim 39 , wherein said positioning system is a processor further comprising a stored software program cooperative with said processor.

56 . The method according to claim 39 , wherein said elongating member is formed from a plurality of flexible parts.

57 . The method according to claim 56 , wherein said plurality of flexible parts are hollow.

58 . The method according to claim 39 , comprising the step of coupling an operative tool to said elongating member.

59 . The method according to claim 58 , wherein said operative tool comprises, a device for ablating, or a device for degrading a cell, a mass of cells, a tissue, or an assembly of cells exhibiting shear strength.

60 . The method according to claim 39 , comprising the step of coupling a vacuum, a siphon, or an evacuation device to said elongating member.

61 . The method according to claim 39 , comprising coupling a device for cauterizing or sealing a cell, a mass of cells, a tissue, or an assembly of cells exhibiting shear strength to said elongating member.

62 . The method according to claim 39 , comprising the step of coupling a stent to said elongating member.

63 . The method according to claim 39 , wherein said signal detector includes an imager, a pressure sensor, a temperature sensor, a chemical sensor, a gas sensor, an electrolyte sensor, a sensor of composition, a sensor of concentration, or a flow sensor coupled to said elongating member.

64 . The method according to claim 39 , further comprising the step of configuring said device for managing a response.

65 . A method for managing perfusion, comprising:

generating a signal from a first location within an animal said signal retrievable by a signal capture tool coupled to a flexible conduit;

transmitting said signal to a guiding system coupled to said flexible conduit;

monitoring said signal at said second location or a new location; and

performing an action with said guiding system responsive to said signal.

66 . The method for perfusion management according to claim 65 , comprising the step of detecting a level of pressure, temperature, chemical, gas, composition, concentration, electrolyte, or flow.

67 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of moving or positioning said flexible conduit.

68 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of delivering a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger a molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction.

69 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of delivering two or more of a chemical, a chemical compound, a protein, a lipoprotein, a glycoprotein, a sugar, a lipid, an antigen, an antibody, a cytokine, a peptide, a neurotransmitter, a hormone, an ion, a messenger a molecule, a nucleic acid, an engineered nucleic acid, a nucleic acid vector, a drug, a cell, a cell fragment, a cell organelle, a liposome, a pharmaceutical agent, a biological material, or a biological fraction.

70 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of delivering an electric current or an electromagnetic radiation in proximity to a cell, a mass of cells, a tissue, or an assembly of biological materials exhibiting shear strength.

71 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of directing, blocking, or shunting a liquid flow.

72 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of ablating, degrading, or liquefying a cell, a mass of cells, a tissue, or an assembly of materials exhibiting shear strength.

73 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of evacuating a target.

74 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of cauterizing or sealing a cell, a mass of cells, a tissue, or an assembly of materials exhibiting shear strength.

75 . The method for perfusion management according to claim 65 , wherein said action further comprises the step of dispensing a fluid at a controlled rate.