Compositions for affecting weight loss
View Patent ↗Disclosed are compositions for affecting weight loss comprising a first compound and a second compound, where the first compound is an opioid antagonist and the second compound causes increased agonism of a melanocortin 3 receptor (MC3-R) or a melanocortin 4 receptor (MC4-R) compared to normal physiological conditions. Also disclosed are methods of affecting weight loss, increasing energy expenditure, increasing satiety in an individual, or suppressing the appetite of an individual, comprising identifying an individual in need thereof and treating that individual to antagonize opioid receptor activity and to enhance α-MSH activity.
1. A composition for affecting weight loss comprising:
(a) a sustained release formulation of bupropion or a pharmaceutically acceptable salt thereof in an amount effective to induce weight loss in an individual; and
(b) a sustained release formulation of naltrexone or a pharmaceutically acceptable salt thereof in an amount effective to enhance the weight loss effect of the bupropion or salt thereof;
wherein said composition is in a single oral dosage form fixed combination.
2. The composition of claim 1 , wherein said composition comprises about 5 mg to about 50 mg of naltrexone or a pharmaceutically acceptable salt thereof.
3. The composition of claim 1 , wherein said composition comprises about 30 mg to about 500 mg of bupropion or a pharmaceutically acceptable salt thereof.
4. The composition of claim 1 , wherein said composition comprises about 5 mg to about 50 mg of naltrexone or a pharmaceutically acceptable salt thereof, and about 30 mg to about 500 mg of bupropion or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition for affecting weight loss comprising:
(a) a sustained release formulation of bupropion or a pharmaceutically acceptable salt thereof in an amount effective to induce weight loss in an individual;
(b) a sustained release formulation of naltrexone or a pharmaceutically acceptable salt thereof in an amount effective to enhance the weight-reducing effect of the bupropion or salt thereof; and
a pharmaceutically acceptable excipient, diluent, or carrier, wherein said composition is formulated into a single oral fixed combination dosage form.
6. The pharmaceutical composition of claim 5 , wherein said composition comprises about 5 mg to about 50 mg of naltrexone or a pharmaceutically acceptable salt thereof.
7. The pharmaceutical composition of claim 5 , wherein said composition comprises about 30 mg to about 500 mg of bupropion or a pharmaceutically acceptable salt thereof.
8. The pharmaceutical composition of claim 5 , wherein said composition comprises about 5 mg to about 50 mg of naltrexone or a pharmaceutically acceptable salt thereof, and about 30 mg to about 500 mg of bupropion or a pharmaceutically acceptable salt thereof.