Method for treating obesity
View Patent ↗The present invention relates, in general, to obesity, and, in particular, to a method of treating obesity and minimizing metabolic risk factors associated therewith using, for example, zonisamide or other weight-loss promoting anticonvulsant either alone or in combination with bupropion or other compound that enhances the activity of norepinephrine and/or dopamine via uptake inhibition or other mechanism.
1. A method of reducing the weight of an overweight subject, said method comprising: identifying an overweight subject and administering to said overweight subject a pharmaceutical composition comprising zonisamide, or a pharmaceutically acceptable salt thereof, in an amount effective to reduce the weight of said subject.
2. The method according to claim 1 , wherein said effective amount of zonisamide is in the range of about 50 to about 1000 mg/day.
3. The method according to claim 2 , wherein said effective amount of zonisamide is in the range of about 100 to about 600 mg/day.
4. The method according to claim 1 , wherein said overweight subject is an obese subject.
5. The method according to claim 1 wherein said pharmaceutical compositions is administered by a route selected from the group consisting of oral, parenteral, topical, injection and rectal administration.
6. The method according to claim 5 , wherein said pharmaceutical composition is administered orally to said subject.
7. The method according to claim 1 , wherein said pharmaceutical composition is administered in combination with another therapeutic method commonly used to reduce weight.
8. The method according to claim 7 , wherein said pharmaceutical composition is administered in combination with a reduced calorie diet or increased physical activity.
9. The method according to claim 7 , wherein said pharmaceutical composition is administered in combination with orlistat, phentermine, sibutramine, topiramate, or sibutramine hydrochloride.
10. A method of reducing weight in an overweight subject, said method comprising: identifying an overweight subject and administering to said overweight subject a pharmaceutical composition comprising zonisamide, or a pharmaceutically acceptable salt thereof, in an amount effective to induce weight loss in said subject, wherein the weight loss is ≧5%, or wherein said weight loss continues during the period of administration of said composition comprising zonisamide or a pharmaceutically acceptable salt thereof.
11. The method according to claim 10 , wherein said effective amount of zonisamide is in the range of about 50 to about 100 mg/day.
12. The method according to claim 10 , wherein said effective amount of zonisamide is in the range of about 100 to about 600 mg/day.
13. The method according to claim 10 , wherein said overweight subject is an obese subject.
14. The method according to claim 10 , wherein said pharmaceutical composition is administered by a route selected from the group consisting of oral, parenteral, topical, injection and rectal administration.
15. The method according to claim 14 , wherein said pharmaceutical composition is administered orally to said subject.
16. The method according to claim 10 , wherein said pharmaceutical composition is administered in combination with another therapeutic method commonly used to reduce weight.
17. The method according to claim 16 , wherein said pharmaceutical composition is administered in combination with a reduced calorie diet or increased physical activity.
18. The method according to claim 17 , wherein said pharmaceutical composition is administered in combination with orlistat, phentermine, sibutramine, topiramate, or sibutramine hydrochloride.
19. A method of treating obesity by reducing the weight of an obese subject, said method comprising: identifying an obese subject and administering to said obese subject an effective amount of a pharmaceutical composition comprising zonisamide, or a pharmaceutically acceptable salt thereof.
20. The method according to claim 19 , wherein said effective amount of zonisamide is in the range of about 50 to about 100 mg/day.
21. The method according to claim 19 , wherein said effective amount of zonisamide is in the range of about 100 about 600 mg/day.
22. The method according to claim 19 , wherein said obese subject has a BMI of at least 30 kg/m 2 .
23. The method according to claim 19 , wherein said pharmaceutical composition is administered by a route selected from the group consisting of oral, parenteral, topical, injection and rectal administration.
24. The method according to claim 23 , wherein said pharmaceutical composition is administered orally to said subject.
25. The method according to claim 19 , wherein said pharmaceutical composition is administered in combination with another therapeutic method commonly used to reduce weight.
26. The method according to claim 25 , wherein said pharmaceutical composition is administered in combination with a reduced calorie diet or increased physical activity.
27. The method according to claim 26 , wherein said pharmaceutical composition is administered in combination with orlistat, phentermine, sibutramine, topiramate, or sibutramine hydrochloride.
28. A method of treating obesity by reducing the weight of an obese subject, said method comprising: identifying an obese subject and orally administering to said obese subject a capsule comprising a pharmaceutical composition comprising zonisamide or a pharmaceutically acceptable salt thereof, wherein said subject receives a daily dose of 100 to 600 mg of zonisamide.