IP Library › Granted Patent US 7,678,385
Granted Patent B2
US 7,678,385 · App. 10/834,562 · Granted Mar 16, 2010

Irradiated implantable bone material

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Quick Facts
Patent No.
US 7,678,385
App. No.
10/834,562
Granted
Mar 16, 2010
Kind
B2
Abstract

A method for making an implantable bone material. The method includes providing a bone composition consisting essentially of demineralized human bone, and irradiating the composition at a temperature less than about 0° C.

Claims (18)

1. A method for making an implantable bone material, comprising:

irradiating a bone composition consisting essentially of demineralized human bone, the bone composition having no osteoinductivity prior to the irradiating, at a temperature less than about 0° C., and at a dose of radiation sufficient to increase the osteoinductivity of the bone composition to an Osteoinduction Grading Scale score of at least 2.

2. A method according to claim 1 , wherein irradiating further comprises cooling the composition using dry ice.

3. A method according to claim 1 , wherein irradiating comprises administering a dose of radiation of at least about 1.0 Mrad to the composition.

4. A method according to claim 3 , wherein the dose of radiation is from about 2.0 Mrad to about 10 Mrad.

5. A method according to claim 1 , wherein irradiating comprises administering a sterilizing dose of radiation to the composition.

6. A method according to claim 1 , wherein the composition additionally comprises a carrier.

7. A method according to claim 1 , wherein the composition consists of demineralized human bone powder.

8. A method according to claim 1 , further comprising:

adding a biocompatible carrier after irradiating; and

forming the mixture into an article.

9. A method according to claim 8 , wherein the article is selected from the group consisting of a sheet, an elongated member, a plate, a plug, a ball, and a porous member.

10. A method for improving the osteoinductivity of demineralized bone comprising:

(a) providing a bone composition consisting essentially of demineralized human bone, the bone composition having no osteoinductivity; and

(b) irradiating the bone composition at a temperature less than about 0° C., at a radiation dose sufficient to produce an increase in the osteoinductivity of the bone composition to an Osteoinduction Grading Scale score of at least 2.

11. A method according to claim 10 , wherein the human demineralized bone comprises human demineralized bone powder.

12. A method according to claim 10 , wherein irradiating comprises administering a sterilizing dose of radiation to the composition.

13. A method according to claim 10 , wherein the composition additionally comprises a biocompatible carrier.

Assignments (4)
RELEASE OF SECURITY INTEREST IN PATENTS RECORDED AT REEL 020362/ FRAME 0001 Recorded Nov 23, 2015
From: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
To: LVB ACQUISITION, INC.; BIOMET, INC.
Reel/Frame 037155/0133 →
CHANGE OF NAME Recorded Jun 21, 2013
From: BIOMET MANUFACTURING CORPORATION
To: BIOMET MANUFACTURING, LLC
Reel/Frame 030656/0702 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 8, 2009
From: REDDI, A. HARI
To: BIOMET MANUFACTURING CORP.
Reel/Frame 022518/0342 →
SECURITY AGREEMENT Recorded Dec 10, 2007
From: LVB ACQUISITION, INC.; BIOMET, INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT FOR THE SECURED PARTIES
Reel/Frame 020362/0001 →