Derivatives of amidines, their preparation and their use as medicaments
View Patent ↗Compounds of the formula wherein R 1 is alkyl and R 2 is alkenyl, alkynyl, allenyl or cyanoalkyl, n is 0 or 1, k is an integer from 1 to 3, X is —(CH 2 ) m — and m is 0 or 1; and pharmaceutical salts thereof useful for inhibiting NO synthases and/or monoamine oxydases.
1. A compound of the formula
wherein R1 is alkyl and R2 is selected from the group consisting of alkenyl, alkynyl, allenyl and cyanoalkyl,
R3 hydrogen
A is thiophene and
X is —(CH 2 ) m — and m is 0 or 1;
or a pharmaceutical salt thereof.
2. A compound selected from the group consisting of:
—N-(4-{[methyl-(2-propynyl)amino]methyl}phenyl)-2-thiophenecarboximidamine;
—N′-(4-{[methyl(cyanomethyl)amino]methyl}phenyl)-2-thiophenecarboximidamide;
—N-(4-{[methyl(propyl)amino]methyl }phenyl)-2-thophenecarboximidamide;
—N-(4-{[methyl(3 -cyanoethyl)amino]methyl}phenyl)-2-thiophenecarboximidamide;
—N′-(4-{[methyl(4-pentynyl)amino]methyl}phenyl)-2-thiophenecarboximidamide;
or a pharmaceutical salt thereof.
3. Pharmaceutical composition containing, as active ingredient, a product according to claim 1 or a pharmaceutically acceptable salt of such a compound.