Diphenylisoxazole compounds and hydro isomers thereof

1. A compound of the formula,

or a pharmaceutically acceptable salt, hydrate, solvate, N-oxide or prodrug thereof, wherein:

one of X and Y is O and the other is N or N(R 16 );

ring B is an isoxazolyl, isoxazolinyl, or isoxazolidinyl ring;

R 2 , R 3 , R 4 , R 5 , R 6 , R 9 , R 10 , R 20 , R 30 , and R 40 are each, independently of one another, selected from the group consisting of hydrogen, —OH, —SH, —CN, —NO 2 , —N 3 , halo, fluoro, chloro, bromo, iodo, lower alkyl, substituted lower alkyl, lower heteroalkyl, substituted lower heteroalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, lower haloalkyl, monohalomethyl, dihalomethyl, trihalomethyl, trifluoromethyl, lower alkylthio, substituted lower alkylthio, lower alkoxy, substituted lower alkoxy, methoxy, substituted methoxy, lower heteroalkoxy, substituted lower heteroalkoxy, cycloalkoxy, substituted cycloalkoxy, cycloheteroalkoxy, substituted cycloheteroalkoxy, lower haloalkoxy, monohalomethoxy, dihalomethoxy, trihalomethoxy, trifluoromethoxy, amino, lower di- or monoalkylamino, substituted lower di- or monoalkylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, phenoxy, substituted phenoxy, arylalkyl, substituted arylalkyl, arylalkyloxy, substituted arylalkyloxy, benzyl, benzyloxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylalkyl, substituted heteroarylalkyl, heteroarylalkyloxy, substituted heteroarylalkyloxy, carboxyl, lower alkoxycarbonyl, substituted lower alkoxycarbonyl, aryloxycarbonyl, substituted aryloxycarbonyl, arylalkyloxycarbonyl, substituted arylalkyloxycarbonyl, carbamate, substituted carbamate, carbamoyl, substituted carbamoyl, sulfamoyl, substituted sulfamoyl and a group of the formula -L-R 14 , where “L” is a linker and R 14 is cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl,

provided that one and only one of R 20 , R 30 , and R 40 is —N(R 11 )C(O)R 12 ; and

provided that when ring B is isoxazolyl, then R 30 is not —N(R 11 )C(O)R 12 ;

R 11 is hydrogen or lower alkyl;

R 12 is monohalomethyl or dihalomethyl; and

R 16 is selected from the group consisting of hydrogen, lower alkyl, substituted lower alkyl, lower heteroalkyl, substituted lower heteroalkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl, lower haloalkyl, monohalomethyl, dihalomethyl, trihalomethyl, trifluoromethyl, lower alkylthio, substituted lower alkylthio, lower alkoxy, substituted lower alkoxy, methoxy, substituted methoxy, lower heteroalkoxy, substituted lower heteroalkoxy, cycloalkoxy, substituted cycloalkoxy, cycloheteroalkoxy, substituted cycloheteroalkoxy, lower haloalkoxy, monohalomethoxy, dihalomethoxy, trihalomethoxy, trifluoromethoxy, lower di- or monoalkylamino, substituted lower di- or monoalkylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, phenoxy, substituted phenoxy, arylalkyl, substituted arylalkyl, arylalkyloxy, substituted arylalkyloxy, benzyl, benzyloxy, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylalkyl, substituted heteroarylalkyl, heteroarylalkyloxy, substituted heteroarylalkyloxy, carboxyl, lower alkoxycarbonyl, substituted lower alkoxycarbonyl, aryloxycarbonyl, substituted aryloxycarbonyl, arylalkyloxycarbonyl, substituted arylalkyloxycarbonyl, carbamate, substituted carbamate, carbamoyl, substituted carbamoyl, sulfamoyl, substituted sulfamoyl and a group of the formula -L-R 14 , where “L” is a linker and R 14 is cycloalkyl, substituted cycloalkyl, cycloheteroalkyl or substituted cycloheteroalkyl.

2. The compound of claim 1 , of one of the formulas,

3. The compound of claim 2 , of one of the formulas,

4. The compound of claim 2 , of one of the formulas,

5. The compound of claim 2 , of one of the formulas,

6. The compound of claim 1 , of one of the formulas,

7. The compound of claim 6 , of one of the formulas,

8. The compound of claim 6 , of one of the formulas,

9. The compound of claim 6 , of one of the formulas,

10. The compound of claim 1 , of one of the formulas,

11. The compound of claim 10 , of one of the formulas,

12. The compound of claim 10 , of one of the formulas,

13. The compound of claim 10 , of one of the formulas,

14. The compound of claim 1 , of one of the formulas,

15. The compound of claim 14 , of one of the formulas,

16. The compound of claim 14 , of one of the formulas,

17. The compound of claim 14 , of one of the formulas,

18. The compound of claim 1 , of one of the formulas,

19. The compound of claim 18 , of one of the formulas,

20. The compound of claim 18 , of one of the formulas,

21. The compound of claim 1 which is,

2,2-Dichloro-N-[2-[3-(2,6-dichlorophenyl)-5-isoxazolyl]phenyl]acetamide;

2,2-Dichloro-N-[4-[3-(2,6-dichlorophenyl)-5-isoxazolyl]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolinyl)]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolinyl)]phenyl]acetamide;

(R)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolinyl)]phenyl]acetamide;

(S)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolinyl)]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(4-isoxazolinyl)]phenyl]acetamide;

(R)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(4-isoxazolinyl)]phenyl]acetamide;

(S)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(4-isoxazolinyl)]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(3-isoxazolinyl)]phenyl]acetamide;

(R)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(3-isoxazolinyl)]phenyl]acetamide;

(S)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(3-isoxazolinyl)]phenyl]acetamide;

cis-(±)-2,2-Dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(±)-2,2-Dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

cis-(3S,5R)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

cis-(3R,5S)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(3S,5S)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(3R,5R)-2,2-dichloro-N-[3-[3-(2,6-dichlorophenyl)-5-(2-isoxazolidinyl)]phenyl]acetamide;

cis-(±)-(±)-2,2-Dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(±)-2,2-Dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

cis-(3R,5S)-2,2-dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

cis-(3S,5R)-2,2-dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(3S,5S)-2,2-dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

trans-(3R,5R)-2,2-dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(2-isoxazolidinyl)]phenyl]acetamide;

2,2-Dichloro-N-[4-[3-(2-chlorophenyl)-5-isoxazolyl]phenyl]acetamide;

2,2-Dichloro-N-[4-[3-(2,6-difluorophenyl)-5-isoxazolyl]phenyl]acetamide;

2,2-Dichloro-N-[2-[3-(2,6-dichlorophenyl)-5-isoxazolyl]phenyl]acetamide;

2,2-Dichloro-N-[4-[5-(2,6-dichlorophenyl)-3-isoxazolyl]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(4-isoxazolinyl)]phenyl]acetamide;

(±)-2,2-Dichloro-N-[3-[5-(2,6-dichlorophenyl)-3-(3-isoxazolinyl)]phenyl]acetamide;

or a pharmaceutically acceptable salt, hydrate, solvate, or N-oxide thereof.