Chemokine receptor binding heterocyclic compounds

1. A method to treat HIV or rheumatoid arthritis in a subject which method comprises administering to a subject in need of such treatment an effective amount of a compound of formula I

or pharmaceutically acceptable acid addition salts, and any stereoisomeric forms and mixtures of stereoisomeric forms thereof: and optionally one or more agent useful in the treatment HIV;

wherein, W is a nitrogen atom and Y is void or, W is a carbon atom and Y=H;

R 1 to R 7 may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C 1–6 alkyl, where R 1 and R 2 together may form ═O;

R 8 is a substituted heterocyclic group or a substituted aromatic group

Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups;

n and n′ are independently, 0–2;

X is a group of the formula:

wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom;

wherein Ring B is an optionally substituted 5 to 7-membered ring;

wherein Ring A or Ring B are bound to group W from any position through group V;

wherein V is a chemical bond or V is a (CH 2 ) n ″group, (where n″=0–2) or V is a C═O group; and

wherein Z is selected from the group consisting of: a hydrogen atom; an optionally substituted C 1–6 alkyl group; a C 0–6 alkyl group substituted with an optionally substituted aromatic or heterocyclic group; an optionally substituted C 0–6 alkylamino or C 3–7 cycloalkylamino group; and an optionally substituted carbonyl group or sulfonyl,

thereby treating HIV or rheumatoid arthritis in said subject.

2. The method of claim 1 , comprising administering the compound of formula I and one or more agents useful in the treatment of HIV.

3. The method of claim 2 , wherein said one or more agents are selected from the group consisting of: nucleotide reverse transcriptase inhibitor such as zidovudine, didanosine, lamivudine, zalcitabine, abacavir, stavudine, adefovir, adefovir dipivoxil, fozivudine todoxil; non-nucleotide reverse transcriptase inhibitor such as nevirapine, delavirdine, efavirenz, loviride, immunocal, or oltipraz; and protease inhibitors such as saquinavir, ritonavir, indinavir, nelfinavir, amprenavir, palinavir, and lasinavir.

4. The method of claim 1 , wherein said optionally substituted 5 or 6-membered Ring A in said compound of formula 1 is selected from the group consisting of: benzene; pyridine; pyrimidine; pyrazine; pyridazine; triazine; piperidine; piperazine; imidazole; pyrazole; triazole; oxazole; and thiazole, or

wherein said optionally substituted Ring B in said compound of formula 1 is selected from the group consisting of: benzene; 5 to 7-membered cycloalkyl ring; furan; dihydrofuran; tetrahydrofuran; thiophene; dihydrothiophene; tetrahydrothiophene (thiolane); pyran; dihydropyran; tetrahydropyran; thiapyran; dihydrothiapyran; tetrahydrothiapyran (pentamethylene sulfide); oxepine; and thiepin.

5. The method of claim 4 , wherein said Ring B comprises a 5 to 7-membered cycloalkyl ring selected from the group consisting of: cyclopentyl; cyclohexyl; cycloheptyl; cyclopentenyl; cyclohexenyl; and cycloheptenyl.

6. The method of claim 1 , wherein said Ring B in said compound of formula 1 comprises a saturated heterocycloalkane.

7. The method of claim 1 , wherein said Ring A and said Ring B in said compound of formula 1 are each 6-membered rings, independently selected from the group consisting of: dihydronaphthalene; tetrahydronaphthalene; dihydroquinoline and tetrahydroquinoline.

8. A method for treating rheumatoid arthritis or HIV in a subject, comprising administering a compound selected from the group consisting of:

AMD7490, N-(2-pyridinylmethyl)-N′-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl) -1,4-benzenedimethanamine;

AMD7491, N-(2-pyridinylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7492, N-(2-pyridinylmethyl)-N′-(6,7dihydro-5H-cyclopenta[b]pyridin-7-y1)-1,4-benzenedimethanamine;

AMD8766, N-(2-pyridinylmethyl)-N′-(1,2,3,4-tetrahydro-1-naphthalenyl)-1,4-benzenedimethanamine;

AMD8789, N-(2-pyridinylmethyl)-N′-(1-naphthalenyl)-1,4-benzenedimethanamine;

AMD8776, N-(2-pyridinylmethyl)-N′-(8-quinolinyl)-14-benzenedimethanamine;

AMD8859, N-(2-pyridinylmethyl)-N′-[2-[(2-pyridinylmethyl)amino]ethyl]-N′-(1-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8867, N-(2-pyridinylmethyl)-N′-[2-[(1H-imidazol-2-ylmethyl)amino]ethyl]-N′-(1-methyl-1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzene dimethanamine;

AMD8746, N-(2-pyridinylmethyl)-N′-(1,2,3,4-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8835, N-(2-pyridinylmethyl)-N′-[2-[(1H-imidazol-2-ylmethyl)amino]ethyl]-N′-(1,2,3,4-tetrahydro-1-naphthalenyl)-1,4-benzene dimethanamine;

AMD8833, N-(2-pyridinylmethyl)-N′-(2-phenyl-5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8825, N,N′-bis(2-pyridinylmethyl)-N′-(2-phenyl-5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8869, N-(2-pyridinylmethyl)-N′-(5,6,7,8-tetrahydro-5-quinolinyl)-1,4-benzenedimethanamine;

AMD8876, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-5-quinolinyl)-1,4-benzenedimethanamine;

AMD8751, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8777, N-(2-pyridinylmethyl)-N′-[(2-amino-3 -phenyl)propyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8763, N-(2-pyridinylmethyl)-N′-(1H-imidazol-4-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8771, N-(2-pyridinylmethyl)-N′-(2-quinolinylmethyl)-N′-(5,6,7,8-tetrahydro-8 -quinolinyl)-1,4-benzenedimethanamine;

AMD8778, N-(2-pyridinylmethyl)-N′-(2-(2-naphthoyl)aminoethyl)-N′-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD8781, N-(2-pyridinylmethyl)-N′-[(S)-(2-acetylamino-3 -phenyl)propyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8782, N-(2-pyridinylmethyl)-N′-[(S)-(2-acetylamino-3 -phenyl)propyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8788, N-(2-pyridinylmethyl)-N′-[3 -((2-naphthalenylmethyl)amino)propyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8733 and AMD8734, N-(2-pyridinylmethyl)-N′-[2-(S)-pyrollidinylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8756, N-(2-pyridinylmethyl)-N′-[2-(R)-pyrollidinylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8799, N-(2-pyridinylmethyl)-N′-[3 -pyrazolylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8728, N-(2-pyridinylmethyl)-N′-[2-pyrrolylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8836, N-(2-pyridinylmethyl)-N′-[2-thiopheneylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine

AMD8841, N-(2-pyridinylmethyl)-N′-[2-thiazolylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8821, N-(2-pyridinylmethyl)-N′-[2-furanylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8742, N-(2-pyridinylmethyl)-N′-[2-[(phenylmethyl)amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8743, N-(2-pyridinylmethyl)-N′-(2-aminoethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl) -1,4-benzenedimethanamine;

AMD8753, N-(2-pyridinylmethyl)-N′-3 -pyrrolidinyl-N′-(5,6,7,8-tetrahydro-8-quinolinyl) -1,4-benzenedimethanamine

AMD8754, N-(2-pyridinylmethyl)-N′-4-piperidinyl-N′-(5,6,7,8-tetrahydro-8-quinolinyl) -1,4-benzenedimethanamine;

AMD8784, N-(2-pyridinylmethyl)-N′-[2-[(phenyl)amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8759, N-(2-pyridinylmethyl)-N′-(7-methoxy- 1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8762, N-(2-pyridinylmethyl)-N′-(6-methoxy- 1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8770, N-(2-pyridinylmethyl)-N′-(1-methyl-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8790, N-(2-pyridinylmethyl)-N′-(7-methoxy-3,4-dihydronaphthalenyl)-1-(aminomethyl)-4-benzamide;

AMD8805, N-(2-pyridinylmethyl)-N′-(6-methoxy-3,4-dihydronaphthalenyl)-1-(aminomethyl)-4-benzamide;

AMD8902, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(7-methoxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8863, N-(2-pyridinylmethyl)-N′-(8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8886, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8889, N-(2-pyridinylmethyl)-N′-(8-Fluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8895, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(8-Fluoro-1,2,3,4-tetrahydro-2-naphthalenyl)-1,4-benzenedimethanamine;

AMD8852, N-(2-pyridinylmethyl)-N′-(5,6,7,8-tetrahydro-7-quinolinyl)-1,4-benzenedimethanamine;

AMD8858, N-(2-pyridinylmethyl)-N′-(1H-imidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-7-quinolinyl)-1,4-benzenedimethanamine;

AMD8785, N-(2-pyridinylmethyl)-N′-[2-[(2-naphthalenylmethyl) amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8820, N-(2-pyridinylmethyl)-N′-[2-(isobutylamino)ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8827, N-(2-pyridinylmethyl)-N′-[2-[(2-pyridinylmethyl) amino]ethyl]-N′-(5,6,7,8-tetrahydro-8 -quinolinyl)-1,4-benzenedimethanamine;

AMD8828, N-(2-pyridinylmethyl)-N′-[2-[(2-furanylmethyl)amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8772, N-(2-pyridinylmethyl)-N′-(2-guanidinoethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine; and

AMD8861, N-(2-pyridinylmethyl)-N′-[2-[bis-[(2-methoxy)phenylmethyl]amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzene dimethanamine;

AMD8862, N-(2-pyridinylmethyl)-N′-[2-[(1H-imidazol-4-ylmethyl)amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzene dimethanamine;

AMD8887, N-(2-pyridinylmethyl)-N′-[2-[(1H-imidazol-2-ylmethyl)amino]ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8816, N-(2-pyridinylmethyl)-N′-[2-(phenylureido)ethyl]-N′-(5,6,7,8 -tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8737, N-(2-pyridinylmethyl)-N′-[[N″-(n-butyl)carboxamido]methyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8739, N-(2-pyridinylmethyl)-N′-(carboxamidomethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8752, N-(2-pyridinylmethyl)-N′-[(N″-phenyl)carboxamidomethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8765, N-(2-pyridinylmethyl)-N′-(carboxymethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8715, N-(2-pyridinylmethyl)-N′-(phenylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl) -1,4-benzenedimethanamine;

AMD8907, N-(2-pyridinylmethyl)-N′-(1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8927, N-(2-pyridinylmethyl)-N′-(5,6-dimethyl-1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine (hydrobromide salt);

AMD8926, N-(2-pyridinylmethyl)-N′-(5-nitro-1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8929, N-(2-pyridinylmethyl)-N′-[(1H)-5-azabenzimidazol-2-ylmethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8931, N-(2-pyridinylmethyl)-N-(4-phenyl-1H-imidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8783, N-(2-pyridinylmethyl)-N′-[2-(2-pyridinyl)ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8764, N-(2-pyridinylmethyl)-N′-(2-benzoxazolyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8780, N-(2-pyridinylmethyl)-N′-trans-2-aminocyclohexyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8818, N-(2-pyridinylmethyl)-N′-(2-phenylethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl) -1,4-benzenedimethanamine;

AMD8829, N-(2-pyridinylmethyl)-N′-(3 -phenylpropyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8839, N-(2-pyridinylmethyl)-N′-(trans-2-aminocyclopentyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8726, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8 -quinolinyl)-glycinamide;

AMD8738, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-(L)-alaninamide;

AMD8749, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-(L)-aspartamide

AMD8750, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-pyrazinamide;

AMD8740, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-(L)-prolinamide;

AMD8741, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8 -quinolinyl)-(L)-lysinamide;

AMD8724, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-benzamide;

AMD8725, N-[[4-[[(2-pyridinylmethyl)amino]methyl]phenyl]methyl]-N-(5,6,7,8-tetrahydro-8-quinolinyl)-picolinamide;

AMD8713, N′-Benzyl-N-[[4-[[(2-pyridinylmethyl) amino]methyl]phenyl]methyl]-N -(5,6,7,8-tetrahydro-8-quinolinyl)-urea;

AMD8712, N′-phenyl-N-[[4-[[(2-pyridinylmethyl) amino]methyl]phenyl]methyl]-N -(5,6,7,8-tetrahydro-8-quinolinyl)-urea;

AMD8716, N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-4-[[(2-pyridinylmethyl)amino]methyl]benzamide;

AMD8717, N-(5,6,7,8-tetrahydro-8-quinolinyl)-4-[[(2-pyridinylmethyl)amino]methyl]benzamide;

AMD8634, N,N′-bis(2-pyridinylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8774, N,N′-bis(2-pyridinylmethyl)-N′-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-l ,4-benzenedimethanamine;

AMD8775, N,N′-bis(2-pyridinylmethyl)-N′-(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl) -1,4-benzenedimethanamine;

AMD8819, N,N′-bis(2-pyridinylmethyl)-N′-(1,2,3,4-tetrahydro-1-naphthalenyl)-1,4-benzenedimethanamine;

AMD8768, N,N′-bis(2-pyridinylmethyl)-N′-[(5,6,7,8-tetrahydro-8-quinolinyl)methyl]-1,4-benzenedimethanamine;

AMD8767, N,N′-bis(2-pyridinylmethyl)-N′[(6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl)methyl]-1,4-benzenedimethanamine;

AMD8838, N-(2-pyridinylmethyl)-N-(2-methoxyethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8871, N-(2-pyridinylmethyl)-N-[2-(4-methoxyphenyl)ethyl]-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD8844, N,N′-bis(2-pyridinylmethyl)-1,4-(5,6,7, 8-tetrahydro-8-quinolinyl)benzenedimethanamine;

AMD7129, N-[(2,3 -dimethoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7138, N-[(2-hydroxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7140, N-[(4-cyanophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7, 8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7141, N-[(4-cyanophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7142, N-[(4-acetamidophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD7145, N[(4-phenoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7151, N-[(4-benzyloxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; and

AMD7155, N-[(thiophene-2-yl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine.

AMD7164, N-[(3,4-methylenedioxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7167, N-[(3,4-methylenedioxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7168, N-(3 -pyridinylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7171, N-[(1,5-dimethyl-2-phenyl-3-pyrazolinone-4-yl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7172, N-[(4-propoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7175, N-(1-phenyl-3,5-dimethylpyrazolin-4-ylmethyl)-N′-(2-pyridinylmethyl)-N -(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7180, N-[(3 -methoxy-4,5 -methylenedioxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N -(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7182, N-[(3 -cyanophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7184, N-[(3 -cyanophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7185, N-(5-ethylthiophene-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7186, N-(5-ethylthiophene-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD7187, N-[(2,6-difluorophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7188, N-[(2,6-difluorophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD7189, N-[(2-difluoromethoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7195, N-(2-difluoromethoxyphenylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8quinolinyl)-1,4-benzenedimethanamine;

AMD7196, N-(1,4-benzodioxan-6-ylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7202, N-(1,4-benzodioxan-6-ylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD7207, N-[(2,4-difluorophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro -8-quinolinyl)-1,4-benzenedimethanamine;

AMD7208, N-(1-methylpyrrol-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)1,4-benzenedimethanamine;

AMD7209, N-[(2-hydroxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)1,4-benzenedimethanamine;

AMD7212, N-[(3 -methoxy-4,5 -methylenedioxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N -(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7216, N-(3 -pyridinylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7222, N-(1-methylbenzimidazol-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7230, N-[1-(ethoxycarbonyl)-4-piperidinyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7231, N-[(1-methyl-3 -pyrazolyl)propyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7236, N-[(1-methyl-2-phenylsulfonyl)ethyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7238, N-[(2-chloro-4,5-methylenedioxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N -(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7239, N-[1-methyl-2-[N″-(4-chlorophenyl)carboxamido]ethyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7241, N-(1-acetoxyindol-3-ylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7242, N-[(3 -benzyloxy-4-methoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7244, N-(3 -quinolylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7245, N-[(8-hydroxy)-2-quinolylmethyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine; and

AMD7247, N-(2-quinolylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7249, N-[(4-acetamidophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7251, N-(3 -quinolylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7252, N-(2-thiazolylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7253, N-(4-pyridinylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7254, N-[(5-benzyloxy)benzo[b]pyrrol-3 -ylmethyl]-N,N′-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine;

AMD7256, N-(1-methylpyrazol-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro -5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7259, N-[[(4-dimethylamino)-1-napthalenyl]methyl]-N,N′-bis(2-pyridinylmethyl)-1,4-benzenedimethanamine;

AMD7270, N-[(2-cyano-2-phenyl)ethyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H -cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7274, N-[(4-dimethylaminophenyl)methyl]-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7275, N-(4-pyridinylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD7276, N-(1-methylbenzimadazol-2-ylmethyl)-N′-(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,4-benzenedimethanamine;

AMD7309, N-[(1-methyl)benzo[b]pyrrol-3 -ylmethyl]-N-[2-(2-pyridinyl)ethyl]-N′-(2-pyridinylmethyl)- 1,3 -benzenedimethanamine;

AMD7374, N-[l -methylbenzimidazol-2-ylmethyl]-N-[2-(2-pyridinyl)ethyl]-N′-(2-pyridinylmethyl)-1,4-benzenedimethanamine;

AMD7379, N-[(2-phenyl)benzo [b]pyrrol-3-ylmethyl]-N-[2-(2-pyridinyl)ethyl]-N′-(2-pyridinylmethyl)-1,4-benzenedimethanamine;

AMD9025, N-[(6-methylpyridin-2-yl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine;

AMD9031, N-(3-methyl-1H-pyrazol-5-ylmethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,3-benzenedimethanamine;

AMD9032, N-[(2-methoxyphenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-13-benzenedimethanamine;

AMD9039, N-[(2-ethoxyphenyl)methyl]-N-′(2-pyridinylmethyl)-N-(6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl)-1,3-benzenedimethanamine;

AMD9045, N-(benzyloxyethyl)-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,3 -benzenedimethanamine;

AMD9052, N-[(2-ethoxy-1-naphthalenyl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,3-benzenedimethanamine; and

AMD9053, N-[(6-methylpyridin-2-yl)methyl]-N′-(2-pyridinylmethyl)-N-(5,6,7,8-tetrahydro-8-quinolinyl)-1,3-benzenedimethanamine.

9. The method of claim 1 , wherein said subject is a mammalian subject.

10. The method of claim 1 , comprising administering the compound of formula I in a subject, thereby treating rheumatoid arthritis.