Synthesis of N-methyl-N-phenylaminoacrolein
View Patent ↗A process is disclosed for manufacturing N-methyl-N-phenylaminoacrolein of formula (I) which comprises reacting N-methylformanilide and an alkyl vinyl ether of formula (III) wherein R is a C 3 –C 4 alkyl, said process being characterized in that the reaction between N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of phosgene, diphosgene or triphosgene in a solvent selected from dioxane, acetonitrile and/or chlorobenzene.
1. A process for manufacturing N-methyl-N-phenylaminoacrolein of formula (I)
comprising the step of reacting N-methylformanilide and an alkyl vinyl ether of formula (III)
wherein R is a C 3 –C 4 alkyl, wherein the reaction between said N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of triphosgene in a solvent selected from the group consisting of dioxane, acetonitrile chlorobenzene and mixtures thereof.
2. A process according to claim 1 , wherein said solvent is chlorobenzene.
3. A process according to claim 1 , wherein R is selected from the group consisting of ethyl, n-propyl, n-butyl, isobutyl and mixtures thereof.
4. A process according to claim 1 , wherein the reaction is carried out at a temperature of 0 to 50° C.
5. A process according to claim 1 , wherein the reaction is carried out at a temperature of 15 to 25° C.
6. A process according to claim 1 , wherein the reacting step further comprises adding at least one of 1.0 to 1.3 equivalents of phosgene, 0.5 to 0.65 equivalents of diphosgene or 0.34 to 0.43 equivalents of triphosgene to an equimolar solution of N-methylformanilide and said alkyl vinyl ether of formula (III).
7. A process for manufacturing N-methyl-N-phenylaminoacrolein of formula (I)
comprising the steps of reacting N-methylformanilide and an alkyl vinyl ether of formula (III)
wherein R is a C 3 –C 4 alkyl, wherein the reaction between said N-methylformanilide and said alkyl vinyl ether of formula (III) is carried out in the presence of triphosgene in a solvent selected from the group consisting of dioxane, acetonitrile chlorobenzene and mixtures thereof
and an aqueous solution of alkaline hydroxide or carbonate to form an aqueous phase and at least one organic phase,
separating the aqueous phase from the at least one organic phase, and evaporating to residue of the at least one organic phase.
8. A process according to claim 1 , further comprising
evaporating the solvent to form a residue and taking up the residue with an aqueous solution of alkaline hydroxide or carbonate and a solvent selected from the group consisting of tert-butyl methyl ether, chlorobenzene, toluene and mixtures thereof.
9. A process according to claim 7 , further comprising the step of extracting the N-methyl-N-phenylaminoacrolein (I) from the aqueous phase with an ether.
10. A process according to claim 9 , wherein said ether is tert-butyl methyl ether.
11. A process according to claim 9 , further comprising the step of recrystallizing the N-methyl-N-phenylaminoacrolein (I) by adding at least one of tert-butyl methyl ether, hexane, heptane, cyclohexane, methanol, ethanol, isopropanol or mixtures thereof to the N-methyl-N-phenylaminoacrolein (I) at a temperature of between −20° C. and 0° C.
12. A process according to claim 1 , wherein the reaction is carried out at a temperature of about 20° C.
13. A process according to claim 10 , wherein tert-butyl methyl ether is used.
14. A process according to claim 10 , wherein the recrystallization step occurs at a temperature of about −15° C.