Quinoline derivatives and quinazoline derivatives
View Patent ↗An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R 1 to R 3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R 4 represents H; R 5 to R 8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R 5 to R 8 do not simultaneously represent H; R 9 and R 10 represent H, alkyl, or alkylcarbonyl; and R 11 represents alkyl, alkenyl, alkynyl, or aralkyl.
1. A compound, wherein said compound is a pharmaceutically acceptable salt or solvate of a member having at least one chemical name selected from the group consisting of N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)-oxy]phenyl}-N′-propylurea, N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′-ethylurea, N-butyl-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′-pentylurea, N-(sec-Butyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, N-allyl-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, and N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′(2-propynyl)urea.
2. The compound according to claim 1 , wherein said compound is a pharmaceutically acceptable salt or solvate of N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)-oxy]phenyl}-N′-propylurea.
3. A method for treating a disease selected from the group consisting of diabetic retinopathy, chronic rheumatism, psoriasis, and atherosclerosis, comprising:
administering, to a subject in need thereof, an effective amount of a compound having at least one chemical name selected from the group consisting of N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)-oxy]phenyl}-N′-propylurea, N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′-ethylurea, N-butyl-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′-pentylurea, N-(sec-Butyl)-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, N-allyl-N′-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}urea, and N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N′(2-propynyl)urea;
or a pharmaceutically acceptable salt or solvate thereof.