Electrodeionization device and methods of use
View Patent ↗The present invention generally relates to purification systems, and to sanitization and/or sealing of the purification system. The purification system includes an electrodeionization device which can comprise one or a plurality of stages. The electrodeionization device can be constructed with a resilient sealing member forming a water-tight seal between rigid thermally and dimensionally stable compartment spacers. The construction of the electrodeionization device may allow cycling of hot water and/or other liquids, which, in some cases, can improve efficiency and performance of the electrodeionization device. Moreover, the cycling of hot water and/or other liquids may be used to sanitize the electrodeionization device to at least a pharmaceutically acceptable condition and, preferably, in certain instances, to meet at least minimum requirements according to U.S. Pharmacopoeia guidelines by inactivating any microorganisms present within the electrodeionization device.
1. A method of inactivating microorganisms in an electrodeionization device comprising:
heating water to at least a pharmaceutically acceptable sanitization temperature externally of the electrodeionization device to produce a disinfecting solution;
introducing the disinfecting solution into the electrodeionization device; and
forcing the disinfecting solution at the at least pharmaceutically acceptable sanitization temperature from the electrodeionization device with water that is at about ambient temperature.
2. The method as in claim 1 , wherein the step of introducing the disinfecting solution into the electrodeionization device comprises forcing liquid at about ambient temperature from the electrodeionization device with the disinfecting solution.
3. The method as claim 1 , further comprising purifying water in the electrodeionization device to produce purified water.
4. The method as in claim 3 , wherein the step of purifying the water in the electrodeionization device is performed with water that is at about ambient temperature.
5. The method as in claim 1 , wherein the electrodeionization device comprises a depleting compartment spacer, a concentrating compartment spacer, a primary seal, and a secondary seal, wherein the primary and secondary seals are disposed between the depleting compartment and the concentrating compartment spacers.
6. The method as in claim 1 , wherein the electrodeionization device comprises a spacer that is dimensionally stable at the at least pharmaceutically acceptable sanitization temperature.
7. The method as in claim 6 , wherein the spacer comprises at least one of polysulfone, polyphenylsulfone, polyphenylene oxide, polyphenylene ether, and chlorinated poly(vinyl chloride).
8. The method as in claim 1 , wherein the electrodeionization device comprises a depleting compartment spacer having a groove formed on a side thereon, a concentrating compartment spacer that mates with the depleting compartment spacer, and a resilient member disposed within the groove forming a water-tight seal between the depleting compartment and the concentrating compartment spacers.
9. The method as in claim 8 , wherein the groove is disposed around a perimeter of the depleting compartment spacer.
10. The method as in claim 8 , wherein the resilient member comprises at least one of a fluorinated elastomer and a silicone elastomer.
11. The method as in claim 1 , wherein the disinfecting solution comprises at least one species selected from the group consisting of phenols, alcohols, halogens, heavy metals, quaternary ammonium compounds, detergents, and aldehydes.
12. The method of claim 1 , further comprising maintaining the temperature of the disinfecting solution at the least pharmaceutically acceptable temperature for a predetermined period that reduces the number of active microorganisms in the electrodeionization device to a pharmaceutically acceptable level.
13. The method of claim 12 , wherein the predetermined period is about sixty minutes.
14. The method of claim 1 , further comprising circulating the disinfecting solution having the at least pharmaceutically acceptable sanitization temperature through the electrodeionization device.
15. The method of claim 14 , wherein the step of circulating the disinfecting solution is performed for about sixty minutes.
16. The method of claim 14 , wherein the step of circulating the disinfecting solution is performed until the number of active microorganisms within the electrodeionization device is reduced to a pharmaceutically acceptable level.