Thienopyridones as AMPK activators for the treatment of diabetes and obesity

1. A compound of formula (I):

or a therapeutically suitable salt, ester or prodrug thereof, wherein

R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, halogen, haloalkyl, trihaloalkyl, heterocycle, hydroxyalkyl, R a R b N—, R a R b Nalkyl, and R c R d NC(O)—, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, HO—, R f S—, and HS—;

R 3 is selected from the group consisting of alkoxycarbonyl, substituted aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, carboxy, carboxylalkyl, halogen, heteroaryl, heterocycle, heterocyclealkyl, R g R j N—, and R g R j Nalkyl, wherein cycloalkyl may be fused to an aryl ring as defined herein;

R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, carboxy, carboxyalkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, hydroxyalkyl, HO—N═CH—(CH 2 ) u —, and R m R n N—;

u is 0, 1 or 2;

R a and R b are each individually selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkoxylcarbonyl, aryl, arylalkyl, arylcarbonyl, arylalkyloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, and heterocycleoxycarbonyl;

R c and R d are each independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, haloalkyl, hydroxyalkyl, and heterocycle;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R g and R j are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, and haloalkyl;

R m and R n are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, heteroaryl, heterocycle, heterocyclealkyl, and haloalkyl; and

R t is selected from the group consisting of hydrogen, alkyl and HO—.

2. The compound of claim 1 , wherein

R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkenyl, alkynyl, carboxy, carboxyalkyl, cyano, cyanoalkyl, halogen, haloalkyl, trihaloalkyl, heterocycle, hydroxyalkyl, R a R b N—, R a R b Nalkyl, and R c R d NC(O)—, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 3 is selected from the group consisting of alkoxycarbonyl, substituted aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, carboxy, carboxylalkyl, halogen, heteroaryl, heterocycle, heterocyclealkyl, R g R j N—, and R g R j Nalkyl, wherein cycloalkyl may be fused to an aryl ring as defined herein;

R 4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, carboxy, carboxyalkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, hydroxyalkyl, HO—N═CH—(CH 2 ) u —, and R m R n N—;

u is 0, 1 or 2;

R a and R b are each individually selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkoxylcarbonyl, aryl, arylalkyl, arylcarbonyl, arylalkyloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, and heterocycleoxycarbonyl;

R c and R d are each independently selected from the group consisting of hydrogen, alkyl, aryl, arylalkyl, haloalkyl, hydroxyalkyl, and heterocycle;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R g and R j are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, and haloalkyl;

R m and R n are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, heteroaryl, heterocycle, heterocyclealkyl, and haloalkyl; and

R t is selected from the group consisting of hydrogen, alkyl and HO—.

3. The compound of claim 1 , wherein

R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 3 is selected from the group consisting of alkoxycarbonyl, substituted aryl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, carboxy, carboxylalkyl, halogen, heteroaryl, heterocycle, heterocyclealkyl, R g R j N—, and R g R j Nalkyl, wherein cycloalkyl may be fused to an aryl ring as defined herein;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, and HO—N═CH—(CH 2 ) u —;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R g and R j are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, and haloalkyl; and

R t is selected from the group consisting of hydrogen, alkyl and HO—.

4. The compound of claim 1 , wherein

R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 3 is selected from the group consisting of alkoxycarbonyl, arylalkyl, arylalkenyl, arylalkynyl, cycloalkyl, carboxy, carboxylalkyl, halogen, heterocyclealkyl, R g R j N—, and R g R j Nalkyl, wherein cycloalkyl may be fused to an aryl ring as defined herein;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, and HO—N═CH—(CH 2 ) u —;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl; and

R t is selected from the group consisting of hydrogen, alkyl and HO—.

5. The compound of claim 1 , wherein

R 1 is selected from the group consisting of hydrogen, alkoxy, alkoxycarbonyl, alkyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 3 is selected from the group consisting of heteroaryl and heterocycle;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, and HO—N═CH—(CH 2 ) u —;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R g and R j are each independently selected from the group consisting of hydrogen, alkyl, alkoxycarbonyl, aryl, arylalkyl, arylcarbonyl, aryloxycarbonyl, heteroaryl, heterocycle, heterocyclealkyl, heterocyclecarbonyl, heterocycleoxycarbonyl, and haloalkyl; and

R t is selected from the group consisting of hydrogen, alkyl and HO—.

6. A compound of formula (II)

or a therapeutically suitable salt, ester or prodrug thereof, wherein

R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkoxycarbonyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, and HO—N═CH—(CH 2 ) u —;

R 5 is selected from the group consisting of alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, cyano, cycloalkylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, hydroxyalkoxy, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, and R r R s NSO 2 alkoxy;

R 6 and R 7 are each individually selected from the group consisting of hydrogen, alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkoxyalkynyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, carboxyalkynyl, cyano, cyanoalkoxy, cyanoalkynyl, cycloalkenylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkoxy, heterocycleoxyalkynyl, hydroxy, hydroxyalkenyl, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, R r R s NC(O)alkynyl, and R r R s NSO 2 alkoxy, R w —O—N═CH—, and R x R y N-alkynyl or R 6 and R 7 together with the atoms to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R p is selected from the group consisting of hydrogen, alkenyl, alkenylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkylcarbonyl, alkyl, alkylcarbonyl, alkynyl, aryl, arylalkenyl, arylalkyl, arylcarbonyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkyl, heterocyclealkylcarbonyl, heterocyclecarbonyl, trihaloalkyl, trihaloalkylcarbonyl, hydroxyalkyl, and hydroxyalkylcarbonyl;

R q are each independently selected from the group consisting of hydrogen, alkyl, alkenyl;

R r and R s are each independently selected from the group consisting of hydrogen, alkyl, arylalkyl, hydroxyalkyl, heterocyclealkyl;

R t is selected from the group consisting of hydrogen, alkyl and HO—;

R w is selected from the group consisting of hydrogen, alkylcarbonyl-NH-alkyl-NHC(O)-alkyl, alkyl, alkyl(alkyl)N-alkyl-NHC(O)-alkyl, hydroxyalkyl-NHC(O)-alkyl, heterocyclealkyl-NHC(O)-alkyl, heterocycle-NHC(O)-alkyl, heteroarylalkyl-NHC(O)-alkyl; and

R x and R y are each individually selected fro the group consisting of hydrogen, alkyl and alkylsulfonyl.

7. The compound of claim 6 , wherein

R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkoxycarbonyl, carboxy, cyano, halogen, hydroxyalkyl, and heterocycle, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, and HO—N═CH—(CH 2 ) u —;

R 5 is selected from the group consisting of alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, cyano, cycloalkylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, hydroxy, hydroxyalkyl, hydroxyalkoxy, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, and R r R s NSO 2 alkoxy;

R 6 and R 7 are each individually selected from the group consisting of hydrogen, alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkoxyalkynyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, carboxyalkynyl, cyano, cyanoalkoxy, cyanoalkynyl, cycloalkenylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkoxy, heterocycleoxyalkynyl, hydroxy, hydroxyalkenyl, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, R r R s NC(O)alkynyl, and R r R s NSO 2 alkoxy, R w —O—N═CH—, and R x R y N-alkynyl or R 6 and R 7 together with the atoms to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl

R p is selected from the group consisting of hydrogen, alkenyl, alkenylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkylcarbonyl, alkyl, alkylcarbonyl, alkynyl, aryl, arylalkenyl, arylalkyl, arylcarbonyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkyl, heterocyclealkylcarbonyl, heterocyclecarbonyl, trihaloalkyl, trihaloalkylcarbonyl, hydroxyalkyl, and hydroxyalkylcarbonyl;

R q are each independently selected from the group consisting of hydrogen, alkyl, alkenyl;

R r and R s are each independently selected from the group consisting of hydrogen, alkyl, arylalkyl, hydroxyalkyl, heterocyclealkyl;

R t is selected from the group consisting of hydrogen, alkyl and HO—;

R w is selected from the group consisting of hydrogen, alkylcarbonyl-NH-alkyl-NHC(O)-alkyl, alkyl, alkyl(alkyl)N-alkyl-NHC(O)-alkyl, hydroxyalkyl-NHC(O)-alkyl, heterocyclealkyl-NHC(O)-alkyl, heterocycle-NHC(O)-alkyl, heteroarylalkyl-NHC(O)-alkyl; and

R x and R y are each individually selected fro the group consisting of hydrogen, alkyl and alkylsulfonyl.

8. The compound of claim 6 , wherein

R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkoxycarbonyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, and HO—N═CH—(CH 2 ) u —;

R 5 is selected from the group consisting of aryl, aryloxy, and heterocycle;

R 6 and R 7 are each individually selected from the group consisting of hydrogen, alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkoxyalkynyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, carboxyalkynyl, cyano, cyanoalkoxy, cyanoalkynyl, cycloalkenylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkoxy, heterocycleoxyalkynyl, hydroxy, hydroxyalkenyl, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, R r R s NC(O)alkynyl, and R r R s NSO 2 alkoxy, R w —O—N═CH—, and R x R y N-alkynyl or R 6 and R 7 together with the atoms to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R p is selected from the group consisting of hydrogen, alkenyl, alkenylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkylcarbonyl, alkyl, alkylcarbonyl, alkynyl, aryl, arylalkenyl, arylalkyl, arylcarbonyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkyl, heterocyclealkylcarbonyl, heterocyclecarbonyl, trihaloalkyl, trihaloalkylcarbonyl, hydroxyalkyl, and hydroxyalkylcarbonyl;

R q are each independently selected from the group consisting of hydrogen, alkyl, alkenyl;

R r and R s are each independently selected from the group consisting of hydrogen, alkyl, arylalkyl, hydroxyalkyl, heterocyclealkyl;

R t is selected from the group consisting of hydrogen, alkyl and HO—;

R w is selected from the group consisting of hydrogen, alkylcarbonyl-NH-alkyl-NHC(O)-alkyl, alkyl, alkyl(alkyl)N-alkyl-NHC(O)-alkyl, hydroxyalkyl-NHC(O)-alkyl, heterocyclealkyl-NHC(O)-alkyl, heterocycle-NHC(O)-alkyl, heteroarylalkyl-NHC(O)-alkyl; and

R x and R y are each individually selected fro the group consisting of hydrogen, alkyl and alkylsulfonyl.

9. A compound of formula (III)

or a therapeutically suitable salt, ester or prodrug thereof, wherein

R 1 is selected from the group consisting of hydrogen, alkyl, alkoxy, alkoxycarbonyl, alkynyl, carboxy, cyano, halogen, heterocycle, and hydroxyalkyl, wherein alkyl may be optionally substituted with O═ and R t —N═;

R 2 is selected from the group consisting of R f O—, and HO—;

R 4 is selected from the group consisting of hydrogen, alkyl, carboxyalkynyl, halogen, haloalkyl, heteroaryl, heterocycle, heterocyclealkyl, and HO—N═CH—(CH 2 ) u —;

R 6 and R 7 are each individually selected from the group consisting of hydrogen, alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkoxyalkynyl, alkyl, alkylcarbonyl, alkoxycarbonylalkoxy, alkynyl, aryl, aryloxy, carboxy, carboxyalkyl, carboxyalkoxy, carboxyalkynyl, cyano, cyanoalkoxy, cyanoalkynyl, cycloalkenylalkoxy, formyl, halo, haloalkyl, trihaloalkyl, trihaloalkoxy, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkoxy, heterocycleoxyalkynyl, hydroxy, hydroxyalkenyl, hydroxyalkyl, hydroxyalkoxy, hydroxyalkynyl, dihydroxyalkoxy, nitro, R p R q N—, R r R s NC(O)alkoxy, R r R s NC(O)alkynyl, and R r R s NSO 2 alkoxy, R w —O—N═CH—, and R x R y NH-alkynyl or R 6 and R 7 together with the atoms to which they are attached form a ring selected from the group consisting of cycloalkyl and heterocycle;

R 8 , R 9 and R 10 are each individually selected from the group consisting of hydrogen, alkenyl, alkenyloxy, alkoxy, alkoxyalkoxy, alkoxycarbonyl, alkoxyalkynyl, alkyl, alkylcarbonyl, alkylSO 2 —, alkoxycarbonylalkoxy, alkynyl, arylalkynyl, aryloxy, carboxy, carboxyalkyl, carboxyalkynyl, carboxyalkoxy, cyano, formyl, halo, haloalkyl, heterocyclealkoxy, heterocycleoxyalkynyl, trihaloalkyl, trihaloalkoxy, hydroxy, hydroxyalkyl, hydroxyalkenyl, hydroxyalkynyl, hydroxyalkoxy, dihydroxyalkoxy, nitro, R u R v N—, R u R v Nalkyl-, R u R v N—C(O)-alkyl-, R u R v Nalkynyl-, R u R v N-C(O)alkynyl-, R r R s NSO 2 —, or R 8 and R 9 taken together with the atoms to which they are attached form a 1,3-dioxolyl ring;

u is 0, 1 or 2;

R f is selected from the group consisting of alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkylthioalkyl, and haloalkyl;

R p is selected from the group consisting of hydrogen, alkenyl, alkenylcarbonyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkoxycarbonylalkylcarbonyl, alkyl, alkylcarbonyl, alkynyl, aryl, arylalkenyl, arylalkyl, arylcarbonyl, haloalkyl, haloalkylcarbonyl, heteroaryl, heterocycle, heterocyclealkenyl, heterocyclealkyl, heterocyclealkylcarbonyl, heterocyclecarbonyl, trihaloalkyl, trihaloalkylcarbonyl, hydroxyalkyl, and hydroxyalkylcarbonyl;

R q are each independently selected from the group consisting of hydrogen, alkyl;

R r and R s are each independently selected from the group consisting of hydrogen, alkyl, arylalkyl, hydroxyalkyl, heterocyclealkyl;

R t is selected from the group consisting of hydrogen, alkyl and HO—;

R u and R v are each individually selected from the group consisting of hydrogen, alkylcarbonyl, alkyl, alkylSO 2 —, alkenyl, arylalkyl,

R w is selected from the group consisting of hydrogen, alkylcarbonyl-NH-alkyl-NHC(O)-alkyl, alkyl, alkyl(alkyl)N-alkyl-NHC(O)-alkyl, hydroxyalkyl-NHC(O)-alkyl, heterocyclealkyl-NHC(O)-alkyl, heterocycle-NHC(O)-alkyl, heteroarylalkyl-NHC(O)-alkyl; and

R x and R y are each individually selected fro the group consisting of hydrogen, alkyl and alkylsulfonyl.

10. The compound that is selected from the group consisting of

3-(3,5-dimethylphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4-fluorophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4-chlorophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-[4-(trifluoromethyl)phenyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(4-chlorophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-6-oxo-3-[4-(trifluoromethyl)phenyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(4-fluorophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-fluoro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-[4′-(trifluoromethyl)-1,1′-biphenyl-4-yl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(1,3-benzodioxol-5-yl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2,5-dibromo-3-(4-chlorophenyl)-4-hydroxythieno[2,3-b]pyridin-6(7H)-one;

2,5-dichloro-3-(4-chlorophenyl)-4-hydroxythieno[2,3-b]pyridin-6(7H)-one;

4-hydroxy-3-(4-nitrophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-3-(4-nitrophenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-methyl-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(3′-methyl-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(3′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-methoxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(3′-methoxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(4′-methoxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-fluoro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3′-fluoro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-chloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3′-chloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-chloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-cyano-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3′-acetyl-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4′-(dimethylamino)-1,1′-biphenyl-4-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(4′-phenoxy-1,1′-biphenyl-4-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-acetyl-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′,3′-dimethyl-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-[4′-(trifluoromethoxy)-1,1′-biphenyl-4-yl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3′,4′-dimethyl-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′,3′-dichloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′,4′-dichloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(4′-fluoro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4-aminophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-6-oxo-3-[4-(trifluoromethyl)phenyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(4′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-acetyl-1,1′-biphenyl-4-yl)-2-bromo-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(4′-cyano-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(5′-bromo-2′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[2′-(hydroxymethyl)-1,1′-biphenyl-4-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[4-(methoxymethoxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-{2′-[({2-[4-(trifluoromethyl)phenyl]ethyl}amino)methyl]-1,1′-biphenyl-4-yl}-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[2′-({[2-(4-hydroxy-3,5-dimethoxyphenyl)ethyl]amino}methyl)-1,1′-biphenyl-4-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(2-formylthien-3-yl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-amino-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(4-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(3-bromo-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-(2′-chloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-[4′-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-1,1′-biphenyl-3-yl]acetamide;

2-chloro-3-(4′-chloro-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

{[4′-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-1,1′-biphenyl-2-yl]oxy}acetic acid;

2-bromo-4-hydroxy-3-(4-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3-bromophenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-(2′-methyl-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-(3′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-{4-[bis(3,3-dimethylbutyl)amino]phenyl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2,5-dichloro-3-(3,5-dichloro-4-hydroxyphenyl)-4-hydroxythieno[2,3-b]pyridin-6(7H)-one;

3-(2′,6′-dihydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(4-aminophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenyl}methanesulfonamide;

2-bromo-3-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′,3′-dihydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2,5-dibromo-3-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxythieno[2,3-b]pyridin-6(7H)-one;

3-(2′,4′-dihydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenyl}methanesulfonamide;

4-hydroxy-3-[5-(4-hydroxyphenyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-[4-(2,3-dihydroxypropoxy)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]benzenesulfonamide;

3-(2′-amino-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5-pyridin-4-ylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-[5-(4-hydroxyphenyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-{5-[4-(hydroxymethyl)phenyl]thien-2-yl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-{4-[(1-hydroxycyclopent-3-en-1-yl)methoxy]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-(4-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-{5-[4-(methylsulfonyl)phenyl]thien-2-yl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenyl}acetamide;

4-hydroxy-6-oxo-3-(5-phenylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2,2′-bithien-5-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3′-fluoro-2′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(2-aminophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(4-fluorophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(2,4-difluorophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(4-thien-3-ylphenyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(3-methoxyprop-1-ynyl)-4-methylthien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(4-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(3-bromo-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2,5-dichloro-4-hydroxy-3-(4-hydroxyphenyl)thieno[2,3-b]pyridin-6(7H)-one;

methyl 4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenylcarbamate;

2-chloro-4-hydroxy-3-[4-(2-hydroxy-2-methylpropoxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-{4-[(1-hydroxycyclopentyl)methoxy]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-3-(4-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-[4-(hydroxymethyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(4-methoxyphenyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-2-methyl-6-oxo-3-(phenylethynyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-{4-[(1-ethyl-4-hydroxypiperidin-4-yl)methoxy]phenyl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(3-methoxyprop-1-ynyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(5-hydroxypent-1-ynyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-{4-[(1-acetyl-4-hydroxypiperidin-4-yl)methoxy]phenyl}-2-chloro-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-3-[4-(4-hydroxybut-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(3-hydroxyprop-1-ynyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-{4-[(4-hydroxy-1-isobutylpiperidin-4-yl)methoxy]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-{4-[(1E)-4-hydroxybut-1-enyl]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-[5-(1,2,3,6-tetrahydropyridin-4-yl)thien-2-yl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5-phenyl-4-pyridin-3-ylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(allyloxy)phenyl]-2-chloro-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

7-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]-N,N-diethylhept-6-ynamide;

4-hydroxy-6-oxo-3-[5-(2-oxo-2,3-dihydro-1H-indol-5-yl)thien-2-yl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(4-cyanophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-{4-[(1-cyclopropyl-4-hydroxypiperidin-4-yl)methoxy]phenyl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4′-fluoro-2′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[4-(methoxymethoxy)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]benzoic acid;

3-[5-(3-aminophenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)thieno[2,3-b]pyridin-6(7H)-one;

methyl 4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)benzoate;

2-chloro-4-hydroxy-6-oxo-3-(2-phenylcyclopropyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(4-acetylphenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(4-vinylphenyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(2,4-dihydroxyphenyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[3-(allyloxy)phenyl]-2-bromo-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-{5-[3-(dimethylamino)prop-1-ynyl]thien-2-yl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[2′-(hydroxymethyl)-1,1′-biphenyl-4-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(4-bromophenyl)-2-chloro-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[4-(4-hydroxybut-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5-pyridin-2-ylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbaldehyde oxime;

3-[3-(allyloxy)phenyl]-2-chloro-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(5′-bromo-2′,4′-dihydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(2′-hydroxy-4′,6′-dimethyl-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]-2-fluorophenyl}acetamide;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-(pyridin-2-ylmethyl)acetamide;

2-chloro-4-hydroxy-3-(5-methyl-2-furyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(3-hydroxyphenyl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-{4-[(1-cyclopentyl-4-hydroxypiperidin-4-yl)methoxy]phenyl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′,5′-dihydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-formyl-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(2,3-dihydroxypropoxy)phenyl]-4-hydroxy-2-methyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(allyloxy)phenyl]-2-bromo-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[5-(1-acetyl-1,2,3,6-tetrahydropyridin-4-yl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-{5-[4-(allyloxy)phenyl]thien-2-yl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

7-[3-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]hept-6-ynoic acid;

4-hydroxy-3-[5-(3-methoxyprop-1-ynyl)-4-vinylthien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-chloro-6′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-4-hydroxy-3-(3′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-{4-[(1-cyclobutyl-4-hydroxypiperidin-4-yl)methoxy]phenyl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

7-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]hept-6-ynoic acid;

3-(3,5-dichloro-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[(2S)-2,3-dihydroxypropyl]acetamide;

4-hydroxy-6-oxo-3-[4-(1H-pyrazol-3-yl)phenyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-{5-[4-(2,3-dihydroxypropoxy)phenyl]thien-2-yl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-4-hydroxy-3-[4-(5-hydroxypent-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5,6,7,8-tetrahydronaphthalen-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[2-(4-methylpiperazin-1-yl)ethyl]acetamide;

N-{3-chloro-4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenyl}acetamide;

4-hydroxy-3-[4-(5-hydroxypent-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-bromo-5-(3-methoxyprop-1-ynyl)thien-2-yl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenoxy]-N-(3-hydroxypropyl)acetamide;

2-chloro-3-[4-(cyanomethoxy)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[4-(3-methoxyprop-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-{4-[(1E)-4-pyrrolidin-1-ylbut-1-enyl]phenyl}-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

tert-butyl 4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)thien-2-yl]phenylcarbamate;

4-hydroxy-3-[5-(4-hydroxyphenyl)-4-methylthien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-chloro-3-[4-(diallylamino)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(1H-indol-5-yl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-bromo-3-(5′-bromo-2′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(5-cyanopent-1-ynyl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenoxy]acetamide;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-(2-pyridin-2-ylethyl)acetamide;

2-chloro-4-hydroxy-3-{4-[(4-hydroxypiperidin-4-yl)methoxy]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2′-amino-1,1′-biphenyl-4-yl)-2-chloro-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(1,2,3,4-tetrahydronaphthalen-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(5-bromothien-2-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(4-nitrophenyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

6-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]hex-5-ynoic acid;

3-[4-(4-cyanobut-1-ynyl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-(pyridin-3-ylmethyl)acetamide;

3-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-2-phenylthien-3-yl]phenyl}methanesulfonamide;

4-hydroxy-6-oxo-3-(5-vinylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5-pyrazin-2-ylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[(1R)-1-(hydroxymethyl)-3-methylbutyl]acetamide;

3-[4-(2-formylthien-3-yl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-{4-[(E)-({2-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-2-oxoethoxy}imino)methyl]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(2,3-dihydro-1H-inden-5-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[5-(4-hydroxybut-1-ynyl)thien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[3-(dimethylamino)propyl]acetamide;

2-[4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenoxy]-N-methylacetamide;

3-[4-(allyloxy)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

{[4′-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-1,1′-biphenyl-2-yl]oxy}acetic acid;

4-hydroxy-3-(4-methylthien-2-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{4-[5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-3-methylthien-2-yl]phenyl}methanesulfonamide;

4-hydroxy-3-[4-(3-hydroxy-3-methylbut-1-ynyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-[2-(acetylamino)ethyl]-2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]acetamide;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-(pyrimidin-4-ylmethyl)acetamide;

4-hydroxy-3-(5-iodo-4-methylthien-2-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

5-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)-N-[2-(dimethylamino)ethyl]thiophene-2-carboxamide;

4-hydroxy-3-{4-[3-(methylamino)prop-1-ynyl]phenyl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[3-(1H-imidazol-1-yl)propyl]acetamide;

3-{5-[(1E)-N-ethoxyethanimidoyl]thien-2-yl}-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(5-pyridin-3-ylthien-2-yl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

7-(5-cyano-4-hydroxy-6-oxo-3-phenyl-6,7-dihydrothieno[2,3-b]pyridin-2-yl)hept-6-ynoic acid;

3-[4-(allyloxy)phenyl]-4-hydroxy-2-methyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenoxy]-N-[3-(2-oxopyrrolidin-1-yl)propyl]acetamide;

4-hydroxy-3-[4-(4-hydroxyphenyl)-5-phenylthien-2-yl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-(3,5-dibromo-4-hydroxyphenyl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[({(1E)-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]methylene}amino)oxy]-N-[2-(1-methylpyrrolidin-2-yl)ethyl]acetamide;

4-hydroxy-6-oxo-3-{4-[3-(tetrahydrofuran-3-yloxy)prop-1-ynyl]phenyl}-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

2-[4-(2-chloro-5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenoxy]-N-[3-(1H-imidazol-1-yl)propyl]acetamide;

3-(1,3-benzodioxol-5-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

5-ethanimidoyl-4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)thieno[2,3-b]pyridin-6(7H)-one;

4-hydroxy-3-{5-[(1E)-N-hydroxyethanimidoyl]thien-2-yl}-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-(3-methyl-1-benzothien-2-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-[(E)-2-phenylvinyl]-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-6-oxo-3-(phenylethynyl)-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

N-{3-[4-(5-cyano-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridin-3-yl)phenyl]prop-2-ynyl}methanesulfonamide;

4-hydroxy-3-[4-(4-hydroxybutyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

3-[4-(4-azidobut-1-ynyl)phenyl]-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

4-hydroxy-3-[4-(5-hydroxypentyl)phenyl]-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile;

ethyl 4-hydroxy-3-(2′-hydroxy-1,1′-biphenyl-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylate; and

3-(2′-fluoro-6′-hydroxy-1,1′-biphenyl-4-yl)-4-hydroxy-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile.

11. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I) of claim 1 in combination with a pharmaceutically suitable carrier.

12. A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (II) of claim 6 in combination with a pharmaceutically suitable carrier.

13. A method of treating diabetes mellitis in a mammal, comprising administering to said mammal in need thereof a therapeutically effective amount of a compound of formula (I) of claim 1 .

14. A method of treating diabetes mellitis in a mammal, comprising administration to mammal in need thereof a therapeutically effective amount of a compound of formula (II) of claim 6 .