Amide substituted imidazoquinolines
View Patent ↗Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.
1. A compound of the formula (Ie):
wherein
R 1 is —C 2-4 alkyl—NR 3 —CO—R 4 ;
R 2 is selected from the group consisting of hydrogen, C 1-4 alkyl, and C 1-4 alkyl—O—C 1-4 alkyl;
R 3 is hydrogen;
R 4 is C 1-8 alkyl; and
n is 0;
or a pharmaceutically acceptable salt thereof.
2. The compound or salt of claim 1 wherein R 2 is C 1-4 alkyl—O—C 1-4 alkyl, and R 4 is cyclohexyl.
3. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
4. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 2 in combination with a pharmaceutically acceptable carrier.