Composition and use
The present invention relates to a composition comprising: (i) an antimicrobial agent; and (ii) a non-ionic co-polymer of Formula ( 1 ) wherein: [A] is of Formula ( 9 ), [B] is of Formula ( 10 ), and [X] is of Formula ( 11 ), wherein [A] and [B] may be in any order; T is an optionally substituted substituent; L is an optionally substituted linking group; R 1 , R 2 and R 3 are each independently H, optionally substituted C 1-20 -alkyl or optionally substituted C 3-20 -cycloalkyl; R 4 and R 5 are each independently H or C 1-4 alkyl; q is 15 to 1000; p is 3 to 50 ; and the molar ratio of [A] to [B] (m:n), is 1:10 to 10:1; provided that R 1 , R 2 , R 3 , T and L do not contain an ionisable group and provided that at least one of R 4 and R 5 is H.
1 . A composition comprising:
(i) an anti-microbial agent comprising a polymeric biguanide, alone or in combination with at least one other microbiologically active component selected from the group consisting of quaternary ammonium compounds, monoquaternary heterocyclic amine salts, urea derivatives, amino compounds, imidazole derivatives, nitrile compounds, tin compounds or complexes, isothiazolin-3-ones, thiazole derivatives, nitro compounds, iodine compounds, aldehyde release agents, thiones, triazine derivatives, oxazolidine and derivatives thereof, furan and derivatives thereof, carboxylic acids and the salts and esters thereof, phenol and derivatives thereof, sulphone derivatives, imides, thioamides, 2-mercapto-pyridine-N-oxide, azole fungicides, strobilurins, amides, carbamates, pyridine derivatives, compounds with active halogen groups, and organometallic compounds; and
(ii) a non-ionic co-polymer of Formula (1)
wherein:
[A] is of Formula (9),
[B] is of Formula (10),
and [X] is of Formula (11),
wherein [A] and [B] may occur in any order;
T is an optionally substituted substituent;
L is an optionally substituted linking group;
R 1 , R 2 and R 3 are each independently H, optionally substituted C 1-20 -alkyl or optionally substituted C 3-20 -cycloalkyl;
R 4 and R 5 are each independently H or C 1-4 alkyl;
q is 15 to 1000;
p is 3 to 50; and
the molar ratio of [A] to [B] (m:n), is 1:10 to 10:1;
provided that R 1 , R 2 , R 3 , T and L do not contain an ionisable group and provided that at least one of R 4 and R 5 is H.
2 . The composition of claim 1 wherein the anti-microbial agent comprises a linear polymeric biguanide.
3 . The composition of claim 1 wherein the polymeric biguanide is a linear polymeric biguanide comprising a mixture of polymer chains in which the individual polymer claims excluding the terminating groups contain at least one recurring unit having two biguanide groups of Formula (4):
wherein d and e represent bridging groups which may be the same or different and in which together the total of the number of carbon atoms directly interposed between the pairs of nitrogen atoms linked by d plus the number of carbon atoms directly interposed between the pairs of nitrogen atoms linked by e is more than 9 and less than 17.
4 . The composition of claim 1 wherein the polymeric biguanide is of Formula (6):
wherein n 1 is from 4 to 20.
5 . The composition of claim 1 wherein the non-ionic co-polymer comprises a cloud point of greater than 15° C.
6 . The composition of claim 1 wherein the non-ionic co-polymer comprises from 10 to 90% by weight of [B] and from 10 to 90% by weight of [A].
7 . The composition of claim 1 wherein R 1 , R 2 and R 3 are each independently H or —CH 3 .
8 . The composition of claim 1 wherein R 4 and R 5 are each independently H.
9 . The composition of claim 1 wherein T comprises a group of the Formula —C(O)OR 6 , wherein R 6 comprises C 1-10 -alkyl; and L comprises a group of the Formula,
10 . The composition of claim 1 wherein the non-ionic co-polymer of Formula (1) comprises [A] of Formula (12),
and [B] of Formula (13),
wherein:
R 1 , R 2 and R 3 is each independently H or CH 3 ;
R 6 is C 1-10 alkyl, optionally substituted by a ketone, ether, —OH, epoxide, silane or keto ester group; and
n, m and p and X are as defined in claim 1 .
11 . The composition of claim 1 wherein the weight ratio of polymeric biguanide to non-ionic co-polymer is from 100:1 to 1:1000 weight percent.
12 . The composition of claim 1 which comprises a pH of from 1 to 12.
13 . The composition of claim 1 wherein the anti-microbial agent comprises a fungicide.
14 . A formulation comprising:
(i) a linear polymeric biguanide;
(ii) a non-ionic co-polymer; and
(iii) a carrier,
wherein the polymeric biguanide and non-ionic co-polymer are as defined in claim 1 .
15 . The formulation of claim 14 wherein the carrier is water or a mixture of water and/or a water miscible organic solvent.
16 . The formulation of claim 14 which comprises from 0.01 to 5% by weight polymeric biguanide and from 0.01 to 50% by weight non-ionic co-polymer.
17 . The formulation of claim 14 which comprises a pH in the range of from 1 to 12.
18 . A method of substantially reducing and sustaining the level of micro-organisms on a surface which comprises contacting the surface with the composition of claim 1 .
19 . A method of substantially reducing and sustaining the level of micro-organisms on a surface which comprises contacting the surface with the formulation of claim 14.