IP Library › Granted Patent US 7,405,277
Granted Patent B2
US 7,405,277 · App. 10/855,013 · Granted Jul 29, 2008

Antibodies against monocyte chemotactic proteins

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Quick Facts
Patent No.
US 7,405,277
App. No.
10/855,013
Granted
Jul 29, 2008
Kind
B2
Abstract

The invention provides antibodies that bind to a plurality of β-chemokines, particularly monocyte chemotactic proteins MCP-1, MCP-2 and MCP-3. The invention also provides cells producing the antibodies, and methods of making and using the same.

Claims (6)

1. An antibody produced by a hybridoma selected from the group consisting of 11K2.1 (ATCC Accession No. PTA-3987), 6D21.1 (ATCC Accession No. PTA-3989), 4N4.1 (ATCC Accession No. PTA-3994), 5A13.1 (ATCC Accession No. PTA-3995), 7H1.1 (ATCC Accession No. PTA-3985), 1A1.1 (ATCC Accession No. PTA-3990), 615.1 (ATCC Accession No. PTA-3986), 2024.1 (ATCC Accession No. PTA-3993), 9B11.1 (ATCC Accession No. PTA-3992), 9B12.1 (ATCC Accession No. PTA-3996), 9C11.1 (ATCC Accession No. PTA-3988), and 12F15.1 (ATCC Accession No. PTA-3991).

2. An antigen-binding fragment of an antibody produced by a hybridoma selected from the group consisting of 11K2.1 (ATCC Accession No. PTA-3987), 6D21.1 (ATCC Accession No. PTA-3989), 4N4.1 (ATCC Accession No. PTA-3994), 5A13.1 (ATCC Accession No. PTA-3995), 7H1.1 (ATCC Accession No. PTA-3985), 1A1.1 (ATCC Accession No. PTA-3990), 615.1 (ATCC Accession No. PTA-3986), 2024.1 (ATCC Accession No. PTA-3993), 9B11.1 (ATCC Accession No. PTA-3992), 9B12.1 (ATCC Accession No. PTA-3996), 9C11.1 (ATCC Accession No. PTA-3988), and 12F15.1 (ATCC Accession No. PTA-3991).

3. The antibody according to claim 1 , wherein said antibody is humanized.

4. The antigen-binding fragment according to claim 2 , wherein said fragment is selected from the group consisting of a Fab fragment, a Fab′ fragment, a F(ab) 2 fragment, and a F v fragment.

5. The antigen-binding fragment according to claim 2 , wherein said fragment is conjugated to polyethylene glycol or albumen.

6. The antigen-binding fragment according to claim 2 , wherein said fragment is humanized.

Assignments (1)
CHANGE OF NAME Recorded May 4, 2015
From: BIOGEN IDEC MA INC.
To: BIOGEN MA INC.
Reel/Frame 035571/0926 →