Treatment and prevention of excessive scarring with 4-hydroxy tamoxifen
View Patent ↗The present invention provides a method for treating or preventing excessive scarring, including keloid and hypertrophic scars, by administering 4-hydroxy tamoxifen to a patient with excessive scarring or a wound at risk for developing excessive scarring.
1. A method of treating or reducing the risk of excessive scars, comprising locally cutaneously administering 4-hydroxy tamoxifen to a site of excessive scarring or a wound or incision at risk for developing excessive scarring.
2. A method according to claim 1 , wherein said site comprises a keloid scar.
3. A method according to claim 1 , wherein said site comprises a wound or incision at risk for developing a keloid scar.
4. A method according to claim 1 , wherein said site comprises a hypertrophic scar.
5. A method according to claim 1 , wherein said site comprises a wound or incision at risk for developing a hypertrophic scar.
6. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is a blend of Z and E isomers.
7. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is predominantly a Z isomer.
8. A method according to claim 1 , wherein between about 0.25 and 3.0 μg of said 4-hydroxy tamoxifen per cm 2 of scar is administered per day.
9. A method according to claim 1 , wherein between about 0.5 and 2.5 μg of said 4-hydroxy tamoxifen per cm 2 of scar is administered per day.
10. A method according to claim 1 , wherein 1.0 μg of said 4-hydroxy tamoxifen per cm 2 of scar is administered per day.
11. A method according to claim 1 , wherein 2.0 μg of said 4-hydroxy tamoxifen per cm 2 of scar is administered per day.
12. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is formulated in a percutaneous administration form selected from the group consisting of: an ointment, a cream, a patch, a gel, an emulsion, a powder, and an oil.
13. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is formulated in a hydroalcoholic gel.
14. A method according to claim 13 , wherein said hydroalcoholic gel comprises ethyl alcohol, isopropyl myristate, and hydroxypropylcellulose.
15. A method according to claim 1 , wherein said 4-hydroxy tamoxifen is formulated in a hydroalcoholic solution.
16. A method according to claim 15 , wherein said hydroalcoholic solution comprises ethyl alcohol, isopropyl myristate and hydroxypropylcellulose.
17. A method according to claim 1 , wherein said vehicle comprises a controlled release polymer that incorporates said 4-hydroxy tamoxifen.
18. A method according to claim 1 , wherein said 4 hydroxy tamoxifen is formulated in a vehicle comprising a penetration enhancer.
19. A composition according to claim 18 , wherein said penetration enhancer comprises isopropyl myristate.