Polymorphic forms of naltrexone
View Patent ↗This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
1. A naltrexone ethylacetate solvate.
2. A naltrexone ethylacetate solvate of claim 1 which is crystalline and is characterized by the X-ray powder diffraction pattern of FIG. 9 .
3. A naltrexone ethylacetate solvate of claim 1 which is crystalline and is characterized by the DSC pattern of FIG. 21 .
4. A naltrexone ethylacetate solvate of claim 1 which is crystalline and is characterized by the IR-ATR of FIG. 33 .
5. A naltrexone ethylacetate solvate of claim 1 which is crystalline and is characterized by at least two of the X-ray powder diffraction pattern of FIG. 9 , the DSC pattern of FIG. 21 and the IR-ATR of FIG. 33 .