Prevention of hyperinsulinemia in subjects undergoing growth hormone (GH) treatment
The present invention provides methods and compositions for preventing hyperinsulinemia that can result from therapeutic administration of growth hormone. The methods are carried out by imposing a restricted high-fat diet and/or by administering one or more drugs that lower serum lipids.
1. A method for reducing the incidence of a statistically significant rise in plasma insulin levels in an animal or human subject undergoing treatment with growth hormone (GH), comprising providing the subject, during the growth hormone treatment period, with a restricted amount of a high-fat (HF) diet as the sole food source.
2. The method of claim 1 , wherein the energy content of the diet does not exceed the theoretical maintenance level for the subject.
3. The method of claim 2 , wherein the subject is a human.
4. The method of claim 3 , wherein the human is obese.
5. The method of claim 1 , wherein the subject is a human.
6. The method of claim 5 , wherein the human is obese.