Enhanced erythropoiesis and iron metabolism
The present invention relates to methods and compounds for regulating or enhancing erythropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
1. A method for treating iron deficiency in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound that stabilizes the alpha subunit of hypoxia-inducible factor (HIFα), thereby treating iron deficiency in the subject.
2. The method of claim 1 , wherein the iron deficiency is associated with anemia.
3. The method of claim 1 , wherein the iron deficiency is associated with a disorder selected from the group consisting of an inflammation, an infection, an immunodeficiency disorder, and a neoplastic disorder.
4. A method for treating functional iron deficiency in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound that stabilizes the alpha subunit of hypoxia-inducible factor (HIFα), thereby treating functional iron deficiency in the subject.
5. The method of claim 1 , wherein the iron deficiency is associated with a disorder selected from the group consisting of anemia of chronic disease, iron deficiency anemia, and microcytic anemia.
6. A method for treating anemia of chronic disease in a subject in need thereof, the method comprising administering to the subject an effective amount of a heterocyclic carboxamide compound that stabilizes the alpha subunit of hypoxia-inducible factor (HIFα), thereby treating anemia of chronic disease in the subject.
7. The method of claim 6 , wherein the anemia of chronic disease is associated with a condition selected from the group consisting of an inflammation, an infection, an immunodeficiency disorder, and a neoplastic disorder.
8. The method of claim 1 , wherein the heterocyclic carboxamide compound inhibits hypoxia-inducible factor prolyl hydroxylase enzyme activity.
9. The method of claim 1 , wherein the heterocyclic carboxamide compound is a structural mimetic of 2-oxoglutarate.
10. The method of claim 4 , wherein the heterocyclic carboxamide compound inhibits hypoxia-inducible factor prolyl hydroxylase enzyme activity.
11. The method of claim 4 , wherein the heterocyclic carboxamide compound is a structural mimetic of 2-oxoglutarate.
12. The method of claim 6 , wherein the heterocyclic carboxamide compound inhibits hypoxia-inducible factor prolyl hydroxylase enzyme activity.
13. The method of claim 6 , wherein the heterocyclic carboxamide compound is a structural mimetic of 2-oxoglutarate.