7, 8 and 9-substituted tetracycline compounds

1. A 7-, 8- or 9-substituted tetracycline compound of the formula:

wherein:

R 4 and R 4′ are each methyl;

R 5 is hydrogen or hydroxyl;

R 6 and R 6′ are each independently hydrogen, methyl, or hydroxyl;

R 7 is furanyl; and

R 8 is hydrogen, phenyl, nitrophenyl, halo, or lower alkynyl;

and R 9 is hydrogen, amino, acetamide, or lower alkynyl;

and pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , wherein R 5 is hydroxyl, R 6 is methyl, and R 6′ is hydrogen.

3. The compound of claim 2 , wherein R 7 is furanyl, and R 8 and R 9 are each hydrogen.

4. The compound of claim 2 , wherein said compound is 7-(2-furanyl) doxycycline.

5. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.

6. The pharmaceutical composition of claim 5 , wherein said compound is 7-(2-furanyl) doxycycline.

7. A method for treating a bacterial infection in a mammal, comprising administering to said mammal a 7, 8 or 9-substituted tetracycline compound of claim 1 .

8. The method of claim 7 wherein said compound is 7-(2-furanyl) doxycycline.

9. The method of claim 7 , wherein said bacterial infection is associated with E. coli.

10. The method of claim 7 , wherein said bacterial infection is associated with S. aureus.

11. The method of claim 7 , wherein said bacterial infection is associated with E. faecalis.

12. The method of claim 7 , wherein said compound is administered with a pharmaceutically acceptable carrier.