Methods of inhibiting metastases

1. A method of inhibiting the development of metastases of a primary tumor to a tissue of a liver in an individual after excision of the primary tumor, comprising directly contacting said tissue with taurolidine isolating said liver from systemic circulation.

2. The method of claim 1 , wherein said primary tumor is not a liver tumor.

3. The method of claim 1 , wherein said primary tumor is in an organ of the peritoneal cavity.

4. The method of claim 1 , wherein said individual is identified as being at risk of developing a metastatic liver tumor.

5. The method of claim 1 , wherein said individual is a mammal.

6. The method of claim 5 , wherein said mammal is a human.

7. The method of claim 1 , wherein said individual is identified as suffering from a colorectal tumor.

8. The method of claim 1 , wherein said individual is identified as suffering from a tumor selected from the group consisting of a lung tumor, breast tumor, kidney tumor, colon tumor, esophageal tumor, testicular tumor, pancreatic tumor, melanoma, and choriocarcinoma.

9. The method of claim 1 , wherein said taurolidine is administered to said liver by perfusion in a direction of naturally-occurring blood flow.

10. The method of claim 1 , wherein said liver is perfused with said taurolidine in situ.

11. The method of claim 1 , wherein said taurolidine is administered to said liver by retrograde perfusion.

12. The method of claim 9 , wherein said perfusion is carried out in conjunction with an abdominal surgery.

13. The method of claim 1 , wherein said Taurolidine is administered by in-dwelling catheter.

14. The method of claim 1 , wherein said Taurolidine is administered at a dose which increased caspase activity in a cell.

15. The method of claim 1 , wherein said Taurolidine is administered intravenously.

16. The method of claim 11 , wherein said perfusion is carried out in conjunction with an abdominal surgery.