5-membered heterocycle-based p38 kinase inhibitors
View Patent ↗Provided are 5-membered heterocycle-based p38 kinase inhibitors. Further provided are pyrazole and imidazole-based p38 kinase, including p38α and p38β kinase, inhibitors. Pharmaceutical compositions containing the compounds are also provided. Methods of use of the compounds and compositions are also provided, including methods of treatment, prevention, or amelioration of one or more symptoms of p38 kinase mediated diseases and disorders, including, but not limited to, inflammatory diseases and disorders.
1. A compound or pharmaceutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
3-(5-amino-4-benzoyl-pyrazol-1-yl)-N-cyclopropyl-4-methyl-benzamide;
3-[5-amino-4-(3-iodo-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide;
3-[5-amino-4-(3-hydroxymethyl-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide;
3-[5-amino-4-(3-hydroxy-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide; and
3-[5-amino-4-(4-methyl-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide.
2. The compound of claim 1 which compound is 3-(5-amino-4-benzoyl-pyrazol-1-yl)-N-cyclopropyl-4-methyl-benzamide, or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1 which compound is 3-[5-amino-4-(3-iodo-benzoyl)-pyrazol-1-yl]N-cyclopropyl-4-methyl-benzamide, or a pharmaceutically acceptable salt thereof.
4. The compound of claim 1 which compound is 3-[5-amino-4-(3-hydroxymethyl-benzoyl)-pyrazol-1-yl]N-cyclopropyl-4-methyl-benzamide, or a pharmaceutically acceptable salt thereof.
5. The compound of claim 1 which compound is 3-[5-amino-4-(3-hydroxy-benzoyl)-pyrazol-1-yl]N-cyclopropyl-4-methyl-benzamide, or a pharmaceutically acceptable salt thereof.
6. The compound of claim 1 which compound is, 3-[5-amino-4-(4-methyl-benzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide or a pharmaceutically acceptable salt thereof.
7. 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methyl-benzamide or a pharmaceutically acceptable salt thereof.