Polyacid glycopeptide derivatives
View Patent ↗Disclosed are derivatives of glycopeptides that are substituted at the C-terminus with a substituent that comprises two or more (e.g. 2, 3, 4, or 5) carboxy (CO 2 H) groups; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
1. A compound of formula II:
wherein
R a is —CH 2 CH 2 —, —CH 2 CH 2 CH 2 — or —CH 2 CH 2 CH 2 CH 2 —;
R b and Z form an n-octyl, n-nonyl, n-decyl, n-undecyl or n-dodecyl group;
or a pharmaceutically acceptable salt or stereoisomer thereof.
2. The compound of claim 1 , wherein R a is —CH 2 CH 2 —.
3. The compound of claim 2 , wherein R b and Z form an n-decyl group.
4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of a compound of any one of claims 1 , 2 or 3 .
5. The pharmaceutical composition of claim 4 , wherein the composition further comprises a cyclodextrin.
6. The pharmaceutical composition of claim 5 , wherein the cyclodextrin is hydroxypropyl-β-cyclodextrin or sulfobutyl ether β-cyclodextrin.
7. A method of treating a bacterial disease in a mammal, the method comprising administering to the mammal a therapeutically effective amount of a compound of any one of claims 1 , 2 or 3 .