Methods of sterilizing polycarbonate articles and methods of manufacture
View Patent ↗A method comprising treating an article with steam, wherein the article comprises a composition comprising an amount of a polysiloxane-polycarbonate copolymer effective to provide thermal and hydrolytic stability to the article for at least 15 cycles, wherein each cycle comprises 20 minutes of contact with steam at 100° C., at atmospheric pressure. The articles are of utility in a wide variety of applications such as food service and medical applications.
1. A method comprising
treating an article with steam, wherein the article comprises a composition comprising an amount of a polysiloxane-polycarbonate copolymer and a copolyester polycarbonate copolymer effective to provide thermal and hydrolytic stability to the article for at least 15 cycles, wherein each cycle comprises 20 minutes of contact with steam at a temperature of 100° C., at atmospheric pressure wherein the polysiloxane-polycarbonate copolymer consists of units derived from a polycarbonate block and a polydiorganosiloxane block and optionally a chain termination agent wherein the copolyester polycarbonate copolymer comprises repeating structural carbonate units of formula (1):
and repeating structural ester units of formula (6):
where at least 60 percent of the total number of R 1 groups are aromatic organic radicals and the balance thereof are aliphatic, alicyclic or aromatic radicals and D is a divalent radical derived from a dihydroxy compound and T is a divalent radical derived from a dicarboxylic acid.
2. The method of claim 1 , wherein the article comprises a composition effective to provide thermal and hydrolytic stability to the article for at least 15 cycles, wherein each cycle comprises 20 minutes of contact with steam at 121° C., at 1.5 atmospheres.
3. The method of claim 1 , wherein the article comprises a composition effective to provide thermal and hydrolytic stability to the article for at least 15 cycles, wherein each cycle comprises 20 minutes of contact with steam at 135° C., at 2.0 atmospheres.
4. The method of claim 1 wherein the polysiloxane-polycarbonate copolymer comprises 0.1 to 40 wt. % of polydimethylsiloxane, or an equivalent molar amount of another polydiorganosiloxane.
5. The method of claim 1 wherein the composition comprises 4 to 100 wt. % polysiloxane-polycarbonate copolymer based on the total weight of the resin composition.
6. The method of claim 1 where the composition comprises 1 to 96 wt. % of the copolyester polycarbonate copolymer, wherein the copolymer has a heat deflection temperature at 1.8 Mpa of greater than 135° C. measured per ASTM D 648.
7. The method of claim 1 where the copolyester polycarbonate copolymer comprises units derived from bis(4-hydroxyphenyl)-p-menthane, 2-phenyl, 3-3-bis(4-hydroxylphenyl)phthalimidine, 4,4′-(hexahydro-4,7-methano-indan-5-ylidene)diphenol, bisphenol(1,3,5-trimethylcyclohexane), 4-[1-[3-(4-hydroxyphenyl)-4-methylcyclohexyl]-1-methylethyl]phenol, 4,4′-[1-methyl-4-(1-methylethyl)-1,3-cyclohexandiyl]bisphenol, phenolphthalein, 2-methyl-3,3-bis(p-hydroxyphenyl)phthalimide, 2-butyl-3,3-bis(p-hydroxyphenyl)phthalimide, 2-octyl-3,3-bis(p-hydroxyphenyl)phthalimide, or a combination comprising at least one of the foregoing, and units derived from an aromatic dicarboxylic acid.
8. The method of claim 1 where treating the article with steam is sufficient to accomplish sterilization.
9. The method of claim 8 , wherein treating the article with steam occurs in an autoclave.
10. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is sufficient to provide the article with a ductility of 50% to 99% after 15 cycles.
11. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is sufficient to provide the article with a Vicat softening temperature of 121° C. to 400° C. after 15 cycles.
12. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is sufficient to provide the article with a notched Izod impact strength of 3 to 18 foot-lbs/inch as determined by ASTM D256 after 15 autoclave cycles.
13. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is sufficient to provide the article with a notched Izod impact retention of 15 to 100% after 15 autoclave cycles, wherein notched Izod impact strength is determined by ASTM D256.
14. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is sufficient to provide the article with a change in yellowness index of less than 20% after 15 autoclave cycles.
15. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is effective to provide the article with a percent haze of 0 to 20% and a percent transmission of 60% to 100% after 15 autoclave cycles.
16. The method of claim 1 wherein the amount of the polysiloxane-polycarbonate copolymer is effective to provide the article with change in any single dimension of less than 10% after 15 autoclave cycles.
17. The method of claim 1 where the article is a medical device.
18. The method of claim 17 wherein the medical device is selected from the group consisting of syringes, blood filter housings, blood bags, solution bags, intravenous connectors, dialyzers, catheters, medical storage trays, medical appliances, medical tubing, cardiac pacemakers and defibrillators, cannulas, implantable prostheses, cardiac assist devices, heart valves, vascular grafts, extra-corporeal devices, artificial organs, pacemaker leads, defibrillator leads, blood pumps, balloon pumps, A-V shunts, biosensors, membranes for cell encapsulation, wound dressings, artificial joints, orthopedic implants and syringes.
19. The method of claim 1 wherein the article is a non-medical device.
20. The method of claim 19 wherein the non-medical device is selected from the group consisting of food trays, animal cages, cable sheathings, varnishes and coatings, structural components for pumps and vehicles, mining ore screens and conveyor belts, laminating compounds, aeronautical applications and chocolate molds.
21. A method comprising
treating an article with steam, wherein the article comprises a composition comprising an amount of polysiloxane-polycarbonate copolymer and a copolyester polycarbonate copolymer sufficient to provide the article with a notched Izod impact retention of 15 to 100% after 15 autoclave cycles, wherein notched Izod impact strength is determined by ASTM D256, and wherein each cycle comprises 20 minutes of contact with steam at a temperature of 100° C., at atmospheric pressure wherein the polysiloxane-polycarbonate copolymer consists of units derived from a polycarbonate block and a polydiorganosiloxane block and optionally a chain termination agent wherein the copolyester polycarbonate copolymer comprises repeating structural carbonate units of formula (1):
and repeating structural ester units of formula (6):
where at least 60 percent of the total number of R 1 groups are aromatic organic radicals and the balance thereof are aliphatic, alicyclic or aromatic radicals and D is a divalent radical derived from a dihydroxy compound and T is a divalent radical derived from a dicarboxylic acid.