Polyalkylene polymer compounds and uses thereof
View Patent ↗The invention relates to novel polyalkylene glycol compounds and methods of using them. In particular, compounds comprising a novel polyethylene glycol conjugate are used alone, or in combination with antiviral agents to treat a viral infection, such as chronic hepatitis C.
1. A composition having the structure according to the formula:
wherein E is hydrogen, a straight- or branched-chain C 1 to C 20 alkyl group, or a detectable label;
a is an integer from 4 to 10,000;
each Z and Z′ is independently hydrogen; a straight- or branched-chain, saturated or unsaturated C 1 to C 20 alkyl or heteroalkyl group; C 3 to C 8 saturated or unsaturated cyclic alkyl or cyclic heteroalkyl; a substituted or unsubstituted aryl or heteroaryl group; or a substituted or unsubstituted alkaryl group wherein the alkyl is a C 1 to C 20 saturated or unsaturated alkyl or heteroalkaryl group, wherein in the substituted groups the substitution is selected from the group consisting of halogen, hydroxyl, carbonyl, carboxylate, ester, formyl, acyl, thiocarbonyl, thioester, thioacetate, thioformate, alkoxyl, phosphoryl, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, an aromatic moiety, a heteroaromatic moiety, imino, silyl, ether, and alkylthio, provided that at least one Z or Z′ is not hydrogen;
R* is a linking moiety formed from the reaction of a moiety selected from the group consisting of aldehyde, aldehyde hydrate, and acetal with B, wherein B is a biologically-active molecule or precursor thereof that comprises interferon-beta-1a (IFN-β-1a);
each n is 0 or an integer from 1 to 5; and
p is 1, 2, or 3.
2. The composition of claim 1 , wherein R* is methylene and wherein B is attached to R* by a bond between the methylene and an amine of the biologically-active molecule.
3. The composition of claim 2 , wherein the amine is an amino terminus of the biologically-active molecule.
4. The composition according to claim 1 having the structure according to the formula:
wherein Z is a straight- or branched-chain, saturated or unsaturated C 1 to C 20 alkyl or heteroalkyl group; C 3 to C 8 saturated or unsaturated cyclic alkyl or cyclic heteroalkyl; a substituted or unsubstituted aryl or heteroaryl group; or a substituted or unsubstituted alkaryl wherein the alkyl is a C 1 to C 20 saturated or unsaturated alkyl or heteroalkaryl group, wherein in the substituted groups the substitution is selected from the group consisting of halogen, hydroxyl, carbonyl, carboxylate, ester, formyl, acyl, thiocarbonyl, thioester, thioacetate, thioformate, alkoxyl, phosphoryl, phosphonate, phosphinate, amino, amido, amidine, imine, cyano, nitro, azido, sulfhydryl, sulfate, sulfonate, sulfamoyl, sulfonamido, sulfonyl, heterocyclyl, aralkyl, an aromatic moiety, a heteroaromatic moiety, imino, silyl, ether, and alkylthio.
5. The composition of claim 4 , wherein Z is methyl and n is one.
6. A pharmaceutical composition comprising the composition according to claim 1 and a pharmaceutically-acceptable carrier.