IP Library › Granted Patent US 7,364,887
Granted Patent B2
US 7,364,887 · App. 10/893,025 · Granted Apr 29, 2008

Use of PAK inhibitor for the treatment of a joint disease

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Quick Facts
Patent No.
US 7,364,887
App. No.
10/893,025
Granted
Apr 29, 2008
Kind
B2
Abstract

The invention refers to the use of a p21-activated kinase (PAK) inhibitor for the treatment of a joint disease such as osteoarthritis or rheumatoid arthritis or for the treatment of a joint pain and the use of PAK as a target protein for the discovery of a PAK inhibitor as a medicament for the treatment of a joint disease.

Claims (5)

1. A method of treating a subject having a degenerative joint disease or an inflammatory joint disease comprising administering to said subject pharmaceutical composition that specifically inhibits p21-activated kinase 1 (PAK1).

2. The method according to claim 1 , wherein said degenerative joint disease is osteoarthritis.

3. The method according to claim 1 , wherein said inflammatory joint disease is rheumatoid arthritis.

4. The method of claim 1 wherein said PAK1 is human PAK1 of SEQ ID NO: 2.

5. The method according to claim 4 , wherein said PAK1 inhibitor has the PAK1 inhibitor domain with the amino acid sequence HTIHVGFDAV TGEFTGMPEQ WARLLQTSNI TKSEQKKNPQ AVLDVLEFYN SKKTSNSQKY MSFTDKS (SEQ ID NO: 6).

Assignments (2)
CHANGE OF NAME Recorded Nov 18, 2005
From: AVENTIS PHARMA DEUTSCHLAND GMBH
To: SANOFI-AVENTIS DEUTSCHLAND GMBH
Reel/Frame 016793/0789 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 17, 2004
From: BARRADEAU, DR. SEBASTIAN; BARTNIK, DR. ECKART; CZECH, DR. JOERG; KLATT, DR. ANDREAS R.; LEBERER, DR. EKKEHARD; LEEUW, DR. THOMAS
To: AVENTIS PHARMA DEUTSCHLAND GMBH
Reel/Frame 015369/0201 →