System and method for conditioning a diaphragm of a patient
A method of conditioning a diaphragm of a patient is provided. The method can include the steps of implanting an electrode adjacent a target site in the diaphragm of the patient and operating the electrode to deliver a sufficient amount of electrical stimulation to the target site in the diaphragm of the patient to cause the diaphragm to contract.
1. A method of treating a neurodegenerative disorder of a patient affecting the patient's diaphragm, the method comprising the steps of:
identifying the patient as having a neurodegenerative disorder;
delivering electrical stimulation to a target site in the diaphragm through an electrode implanted in the diaphragm to contract the diaphragm; and
synchronizing the delivering step with a breath or breathing attempt made by the patient to condition the diaphragm.
2. The method of claim 1 further comprising implanting the electrode adjacent the target site.
3. The method of claim 2 , further comprising the step of:
identifying the target site in the diaphragm of the patient prior to the implanting step.
4. The method of claim 1 , wherein the target site of the diaphragm is the phrenic nerve motor point of a hemidiaphragm of the patient.
5. The method of claim 4 further comprising delivering electrical stimulation to a phrenic nerve motor point in another hemidiaphragm of the patient through a second electrode implanted in the other hemidiaphragm.
6. The method of claim 1 wherein the electrical stimulation is delivered at specified intervals.
7. The method of claim 1 wherein the electrical stimulation has a pulse frequency between about 5 Hz and about 50 Hz.
8. The method of claim 1 wherein the electrical stimulation has a pulse width between about 20 μs and about 200 μs.
9. The method of claim 1 wherein the electrical stimulation has a pulse amplitude between about 5 mA and about 25 mA.
10. The method of claim 1 further comprising the step of:
delivering breathing gas to the patient from a ventilator to assist breathing by the patient at specified gas delivery intervals.
11. The method of claim 10 further comprising the step of:
synchronizing delivery of the breathing gas to the patient by the ventilator with delivery of the electrical stimulation of the target site in the diaphragm of the patient by the electrode.
12. The method of claim 11 wherein electrical stimulation can be delivered to the target site of the diaphragm following the inspiration phase of a breath by the patient.
13. The method of claim 1 wherein the electrical stimulation provides a sufficient number, duration, and range of diaphragm contractions to elicit a change in strength, fatigue resistance, or fiber contractile properties.
14. The method of claim 1 wherein the neurodegenerative disease is amyotrophic lateral sclerosis.